4cli: Difference between revisions
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Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(m etheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of ALK/ROS1 with pre-clinical brain exposure and broad spectrum potency against ALK-resistant mutations.,Johnson TW, Richardson PF, Bailey S, Brooun A, Burke BJ, Collins MR, Cui JJ, Deal JG, Deng YL, Dinh DM, Engstrom LD, He M, Hoffman JE, Hoffman RL, Huang Q, Kath J, Kania RS, Lam H, Lam JL, Le PT, Lingardo L, Liu W, McTigue MA, Palmer CL, Sach NW, Smeal T, Smith GL, Stewart AE, Timofeevski SL, Zhu H, Zhu J, Zou HY, Edwards MP J Med Chem. 2014 May 13. PMID:24819116<ref>PMID:24819116</ref> | Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(m etheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of ALK/ROS1 with pre-clinical brain exposure and broad spectrum potency against ALK-resistant mutations.,Johnson TW, Richardson PF, Bailey S, Brooun A, Burke BJ, Collins MR, Cui JJ, Deal JG, Deng YL, Dinh DM, Engstrom LD, He M, Hoffman JE, Hoffman RL, Huang Q, Kath J, Kania RS, Lam H, Lam JL, Le PT, Lingardo L, Liu W, McTigue MA, Palmer CL, Sach NW, Smeal T, Smith GL, Stewart AE, Timofeevski SL, Zhu H, Zhu J, Zou HY, Edwards MP J Med Chem. 2014 May 13. PMID:24819116<ref>PMID:24819116</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
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== References == | == References == | ||
