3k9v: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "3k9v" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3k9v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9V FirstGlance]. <br> | <table><tr><td colspan='2'>[[3k9v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9V FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k9y|3k9y]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k9y|3k9y]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cyp24, Cyp24a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cyp24, Cyp24a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k9v RCSB], [http://www.ebi.ac.uk/pdbsum/3k9v PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k9v RCSB], [http://www.ebi.ac.uk/pdbsum/3k9v PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CP24A_RAT CP24A_RAT]] Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 26: | ||
Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.,Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD J Mol Biol. 2010 Feb 19;396(2):441-51. Epub 2009 Dec 1. PMID:19961857<ref>PMID:19961857</ref> | Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.,Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD J Mol Biol. 2010 Feb 19;396(2):441-51. Epub 2009 Dec 1. PMID:19961857<ref>PMID:19961857</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
| Line 31: | Line 33: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Annalora, A J | [[Category: Annalora, A J]] | ||
[[Category: Goodin, D B | [[Category: Goodin, D B]] | ||
[[Category: Hong, W | [[Category: Hong, W]] | ||
[[Category: Johnson, E F | [[Category: Johnson, E F]] | ||
[[Category: Stout, C D | [[Category: Stout, C D]] | ||
[[Category: Zhang, Q | [[Category: Zhang, Q]] | ||
[[Category: Adrenodoxin]] | [[Category: Adrenodoxin]] | ||
[[Category: Mitochondrial cytochrome p450]] | [[Category: Mitochondrial cytochrome p450]] | ||
