4aei: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4aei]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEI FirstGlance]. <br> | <table><tr><td colspan='2'>[[4aei]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEI FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1seg|1seg]], [[1ptx|1ptx]], [[1aho|1aho]], [[4aeh|4aeh]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1seg|1seg]], [[1ptx|1ptx]], [[1aho|1aho]], [[4aeh|4aeh]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aei RCSB], [http://www.ebi.ac.uk/pdbsum/4aei PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aei RCSB], [http://www.ebi.ac.uk/pdbsum/4aei PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Androctonus australis hector]] | [[Category: Androctonus australis hector]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Bourne, Y | [[Category: Bourne, Y]] | ||
[[Category: Conrod, S | [[Category: Conrod, S]] | ||
[[Category: Fabrichny, I P | [[Category: Fabrichny, I P]] | ||
[[Category: Marchot, P | [[Category: Marchot, P]] | ||
[[Category: Martin-Eauclaire, M F | [[Category: Martin-Eauclaire, M F]] | ||
[[Category: Mondielli, G | [[Category: Mondielli, G]] | ||
[[Category: Alpha-toxin]] | [[Category: Alpha-toxin]] | ||
[[Category: Combining site]] | [[Category: Combining site]] | ||
