3zuq: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3zuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUQ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s0d|1s0d]], [[1epw|1epw]], [[1g9b|1g9b]], [[1f82|1f82]], [[2etf|2etf]], [[1i1e|1i1e]], [[1s0f|1s0f]], [[2xhl|2xhl]], [[1g9a|1g9a]], [[1g9c|1g9c]], [[1s0b|1s0b]], [[1s0g|1s0g]], [[1g9d|1g9d]], [[1s0c|1s0c]], [[1f31|1f31]], [[1s0e|1s0e]], [[1z0h|1z0h]], [[3zur|3zur]], [[3zus|3zus]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s0d|1s0d]], [[1epw|1epw]], [[1g9b|1g9b]], [[1f82|1f82]], [[2etf|2etf]], [[1i1e|1i1e]], [[1s0f|1s0f]], [[2xhl|2xhl]], [[1g9a|1g9a]], [[1g9c|1g9c]], [[1s0b|1s0b]], [[1s0g|1s0g]], [[1g9d|1g9d]], [[1s0c|1s0c]], [[1f31|1f31]], [[1s0e|1s0e]], [[1z0h|1z0h]], [[3zur|3zur]], [[3zus|3zus]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuq RCSB], [http://www.ebi.ac.uk/pdbsum/3zuq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuq RCSB], [http://www.ebi.ac.uk/pdbsum/3zuq PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Bontoxilysin]] | [[Category: Bontoxilysin]] | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Acharya, K R | [[Category: Acharya, K R]] | ||
[[Category: Chaddock, J A | [[Category: Chaddock, J A]] | ||
[[Category: Masuyer, G | [[Category: Masuyer, G]] | ||
[[Category: Stancombe, P | [[Category: Stancombe, P]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Protein engineering]] | [[Category: Protein engineering]] | ||
