4a7j: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4a7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7J FirstGlance]. <br> | <table><tr><td colspan='2'>[[4a7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7J FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h13|2h13]], [[2h6q|2h6q]], [[2g99|2g99]], [[2co0|2co0]], [[2h6k|2h6k]], [[2cnx|2cnx]], [[2ybp|2ybp]], [[2ybs|2ybs]], [[2g9a|2g9a]], [[2v1d|2v1d]], [[2h6n|2h6n]], [[2gnq|2gnq]], [[2h68|2h68]], [[2h14|2h14]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h13|2h13]], [[2h6q|2h6q]], [[2g99|2g99]], [[2co0|2co0]], [[2h6k|2h6k]], [[2cnx|2cnx]], [[2ybp|2ybp]], [[2ybs|2ybs]], [[2g9a|2g9a]], [[2v1d|2v1d]], [[2h6n|2h6n]], [[2gnq|2gnq]], [[2h68|2h68]], [[2h14|2h14]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a7j RCSB], [http://www.ebi.ac.uk/pdbsum/4a7j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a7j RCSB], [http://www.ebi.ac.uk/pdbsum/4a7j PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> [[http://www.uniprot.org/uniprot/H31T_HUMAN H31T_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Amati, B | [[Category: Amati, B]] | ||
[[Category: Bassi, C | [[Category: Bassi, C]] | ||
[[Category: Bezzi, M | [[Category: Bezzi, M]] | ||
[[Category: Blackstock, W | [[Category: Blackstock, W]] | ||
[[Category: Capasso, P | [[Category: Capasso, P]] | ||
[[Category: Cecatiello, V | [[Category: Cecatiello, V]] | ||
[[Category: Chuenmok, W | [[Category: Chuenmok, W]] | ||
[[Category: Demarco, A | [[Category: Demarco, A]] | ||
[[Category: Guccione, E | [[Category: Guccione, E]] | ||
[[Category: Gunaratne, J | [[Category: Gunaratne, J]] | ||
[[Category: Kuznetsov, V | [[Category: Kuznetsov, V]] | ||
[[Category: Low, D | [[Category: Low, D]] | ||
[[Category: Mapelli, M | [[Category: Mapelli, M]] | ||
[[Category: Migliori, V | [[Category: Migliori, V]] | ||
[[Category: Muller, J | [[Category: Muller, J]] | ||
[[Category: Phalke, S | [[Category: Phalke, S]] | ||
[[Category: Histone methylation]] | [[Category: Histone methylation]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
