1fms

Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)

spinqualitylabelsall models 1fms, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1fms is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: D35, MG Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed 2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds. DNA minor groove interactions and the biological activity of 2,5-bis.,Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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