1bjf: Difference between revisions
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|PDB= 1bjf |SIZE=350|CAPTION= <scene name='initialview01'>1bjf</scene>, resolution 2.4Å | |PDB= 1bjf |SIZE=350|CAPTION= <scene name='initialview01'>1bjf</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bjf OCA], [http://www.ebi.ac.uk/pdbsum/1bjf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bjf RCSB]</span> | |||
}} | }} | ||
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[[Category: Kumar, V D.]] | [[Category: Kumar, V D.]] | ||
[[Category: Vijay-Kumar, S.]] | [[Category: Vijay-Kumar, S.]] | ||
[[Category: calcium-binding]] | [[Category: calcium-binding]] | ||
[[Category: myristoylation]] | [[Category: myristoylation]] | ||
[[Category: neuronal specific guanylate cyclase activator]] | [[Category: neuronal specific guanylate cyclase activator]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:02:16 2008'' | ||
Revision as of 16:02, 30 March 2008
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| 1bjf, resolution 2.4Å | |||||||||||||
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| Ligands: | CA | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS
Overview
The crystal structure of calcium-bound unmyristoylated bovine neurocalcin from Escherichia coli has been determined at 2.4 A resolution. The three-dimensional structure reveals a highly compact structure consisting of: (i) two pairs of calcium-binding EF-hands (EF1-EF2 and EF3-EF4); (ii) a calcium ion bound at EF2, EF3 and EF4 sites; and (iii) an EF1-hand that is disabled from calcium-binding due to a Cys-Pro sequence in the Ca2+-binding loop. The crystal structure of neurocalcin resembles photoreceptor recoverin in overall topology, however its EF2- and EF4-hands differ. Recently, neurocalcin in the calcium-bound state has been shown to stimulate mammalian rod outer segment membrane guanylate cyclase. A possible site for cyclase activity based on the three-dimensional structure is discussed.
About this Structure
1BJF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of recombinant bovine neurocalcin., Vijay-Kumar S, Kumar VD, Nat Struct Biol. 1999 Jan;6(1):80-8. PMID:9886296
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