4tmp: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal structure of AF9 YEATS bound to H3K9ac peptide==

The ~~entry 4tmp~~ is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4tmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TMP FirstGlance].

~~Authors~~: Li, H., Li, Y., Wang, H.~~, Ren, Y.~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tmp RCSB], [http://www.ebi.ac.uk/pdbsum/4tmp PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

== Function ==

[[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Li, H.]]

[[Category: Li, Y.]]

[[Category: Ren, Y.]]

[[Category: Wang, H.]]

[[Category: Complex]]

[[Category: Histone modification]]

[[Category: Immunoglobin fold]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of AF9 YEATS bound to H3K9ac peptide==
+<StructureSection load='4tmp' size='340' side='right' caption='[[4tmp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-The entry 4tmp is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4tmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TMP FirstGlance]. <br>
-Authors: Li, H., Li, Y., Wang, H., Ren, Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tmp RCSB], [http://www.ebi.ac.uk/pdbsum/4tmp PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.
+== Function ==
+[[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Li, H.]]
+[[Category: Li, Y.]]
+[[Category: Ren, Y.]]
+[[Category: Wang, H.]]
+[[Category: Complex]]
+[[Category: Histone modification]]
+[[Category: Immunoglobin fold]]
+[[Category: Transcription]]