3ue8: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ue8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ue8 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Anderson, M | [[Category: Anderson, M]] | ||
[[Category: Bechle, B M | [[Category: Bechle, B M]] | ||
[[Category: Campbell, B M | [[Category: Campbell, B M]] | ||
[[Category: Claffey, M M | [[Category: Claffey, M M]] | ||
[[Category: Dounay, A B | [[Category: Dounay, A B]] | ||
[[Category: Edelweiss, E | [[Category: Edelweiss, E]] | ||
[[Category: Evdokimov, A | [[Category: Evdokimov, A]] | ||
[[Category: Fonseca, K R | [[Category: Fonseca, K R]] | ||
[[Category: Gan, X | [[Category: Gan, X]] | ||
[[Category: Ghosh, S | [[Category: Ghosh, S]] | ||
[[Category: Hayward, M M | [[Category: Hayward, M M]] | ||
[[Category: Horner, W | [[Category: Horner, W]] | ||
[[Category: Kim, J Y | [[Category: Kim, J Y]] | ||
[[Category: McAllister, L A | [[Category: McAllister, L A]] | ||
[[Category: Pandit, J | [[Category: Pandit, J]] | ||
[[Category: Paradis, V | [[Category: Paradis, V]] | ||
[[Category: Parikh, V D | [[Category: Parikh, V D]] | ||
[[Category: Reese, M R | [[Category: Reese, M R]] | ||
[[Category: Rong, S B | [[Category: Rong, S B]] | ||
[[Category: Salafia, M A | [[Category: Salafia, M A]] | ||
[[Category: Schuyten, K | [[Category: Schuyten, K]] | ||
[[Category: Strick, C A | [[Category: Strick, C A]] | ||
[[Category: Tuttle, J B | [[Category: Tuttle, J B]] | ||
[[Category: Valentine, J | [[Category: Valentine, J]] | ||
[[Category: Verhoest, P R | [[Category: Verhoest, P R]] | ||
[[Category: Wang, H | [[Category: Wang, H]] | ||
[[Category: Zawadzke, L E | [[Category: Zawadzke, L E]] | ||
[[Category: Kat ii]] | [[Category: Kat ii]] | ||
[[Category: Kynurenine aminotransferase]] | [[Category: Kynurenine aminotransferase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 20:34, 24 December 2014
Kynurenine Aminotransferase II Inhibitors
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Anderson, M
- Bechle, B M
- Campbell, B M
- Claffey, M M
- Dounay, A B
- Edelweiss, E
- Evdokimov, A
- Fonseca, K R
- Gan, X
- Ghosh, S
- Hayward, M M
- Horner, W
- Kim, J Y
- McAllister, L A
- Pandit, J
- Paradis, V
- Parikh, V D
- Reese, M R
- Rong, S B
- Salafia, M A
- Schuyten, K
- Strick, C A
- Tuttle, J B
- Valentine, J
- Verhoest, P R
- Wang, H
- Zawadzke, L E
- Kat ii
- Kynurenine aminotransferase
- Transferase-transferase inhibitor complex
