Menin: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='4og6' size='340' side='right' caption='Structure of human menin complex with inhibitor (PDB code 4og6).' scene=''> == Function == '''Menin''' (Men) is a puta... |
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<StructureSection load='4og6' size='340' side='right' caption='Structure of human menin complex with piperidine derivative inhibitor, tetraethylene glycol, DMSO and sulfate (PDB code [[4og6]]).' scene=''> | |||
<StructureSection load='4og6' size='340' side='right' caption='Structure of human menin complex with inhibitor (PDB code [[4og6]]).' scene=''> | |||
== Function == | == Function == | ||
Revision as of 09:46, 12 June 2014
<StructureSection load='4og6' size='340' side='right' caption='Structure of human menin complex with piperidine derivative inhibitor, tetraethylene glycol, DMSO and sulfate (PDB code 4og6).' scene=>
Function
Menin (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD.
Disease
Relevance
Structural highlights
3D structures of menin
Updated on 12-June-2014
3u84 – hMen – human
4og3, 4og4, 4og5, 4og6, 4og7, 4og8 – hMen + inhibitor
4gpq, 4gq3, 4gq4 – hMen (mutant) + inhibitor
4i80 – hMen + peptide inhibitor
3u85 – hMen + histone-lysine N-methyltransferase Mll peptide
4gq6 – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide
3u86 – hMen + JunD peptide
3u85 – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor
