Menin: Difference between revisions
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[[3u84]] – hMen – human<br /> | [[3u84]] – hMen – human<br /> | ||
[[4og3]], [[4og4]], [[4og5]], [[4og6]], [[4og7]], [[4og8]] – hMen + inhibitor<br /> | [[4og3]], [[4og4]], [[4og5]], [[4og6]], [[4og7]], [[4og8]] – hMen + inhibitor<br /> | ||
[[4gpq]], [[4gq3]], [[4gq4]] – hMen (mutant) + inhibitor<br /> | [[4gpq]], [[4gq3]], [[4gq4]], [[4x5y]], [[4x5z]] – hMen (mutant) + inhibitor<br /> | ||
[[4i80]] – hMen + peptide inhibitor<br /> | [[4i80]] – hMen + peptide inhibitor<br /> | ||
[[3u85]] – hMen + histone-lysine N-methyltransferase Mll peptide<br /> | [[3u85]] – hMen + histone-lysine N-methyltransferase Mll peptide<br /> | ||
[[4gq6]] – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide<br /> | [[4gq6]] – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide<br /> | ||
[[3u86]] – hMen + JunD peptide<br /> | [[3u86]] – hMen + JunD peptide<br /> | ||
[[ | [[3u88]] – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor<br /> | ||
Revision as of 07:51, 5 May 2015
<StructureSection load='4og6' size='340' side='right' caption='Structure of human menin complex with piperidine derivative inhibitor, tetraethylene glycol, DMSO and sulfate (PDB code 4og6).' scene=>
Function
Menin (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD.
Disease
Relevance
Structural highlights
3D structures of menin
Updated on 05-May-2015
3u84 – hMen – human
4og3, 4og4, 4og5, 4og6, 4og7, 4og8 – hMen + inhibitor
4gpq, 4gq3, 4gq4, 4x5y, 4x5z – hMen (mutant) + inhibitor
4i80 – hMen + peptide inhibitor
3u85 – hMen + histone-lysine N-methyltransferase Mll peptide
4gq6 – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide
3u86 – hMen + JunD peptide
3u88 – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor
