Importin: Difference between revisions

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== Function ==

'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS). ~~IMP~~ has 2 subunits: α and β. IPO-α is an adaptor protein which binds the NLS. Proteins can contain one or two NLS motifs. IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB). IPO-β contains 19 HEAT repeats. Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.

'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS). IPO has 2 subunits: α and β. IPO-α is an adaptor protein which binds the NLS. Proteins can contain one or two NLS motifs. IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB). IPO-β contains 19 HEAT repeats. Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.

== Disease ==

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+<StructureSection load='1ee5' size='340' side='right' caption='Structure of yeast importin α NLS-binding domain (grey) complex with nucleoplasmin peptide (green) (PDB code [[1ee5]]).' scene=''>
-<StructureSection load='1ee5' size='340' side='right' caption='Structure of yeast importin α NLS-binding domain complex with nucleoplasmin peptide (PDB code [[1ee5]]).' scene=''>
 == Function ==
-'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS).  IMP has 2 subunits: α and β.  IPO-α is an adaptor protein which binds the NLS.  Proteins can contain one or two NLS motifs.  IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB).  IPO-β contains 19 HEAT repeats.  Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.
+'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS).  IPO has 2 subunits: α and β.  IPO-α is an adaptor protein which binds the NLS.  Proteins can contain one or two NLS motifs.  IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB).  IPO-β contains 19 HEAT repeats.  Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.
 == Disease ==