4phu: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of Human GPR40 bound to allosteric agonist TAK-875==

~~The entry~~ 4phu is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4phu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHU OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHU FirstGlance].

~~Authors~~: ~~Srivastava~~, A., ~~Yano~~, J.K., ~~Hirozane~~, Y., ~~Kefala~~, G.~~, Snell, G~~., ~~Lane, W~~., Gruswitz, F., Ivetac, A., ~~Aertgeerts~~, K., Nguyen, J., ~~Jennings~~, A., ~~Okada,~~ K.

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2YB:[(3S)-6-({2,6-DIMETHYL-4-[3-(METHYLSULFONYL)PROPOXY]BIPHENYL-3-YL}METHOXY)-2,3-DIHYDRO-1-BENZOFURAN-3-YL]ACETIC+ACID'>2YB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </td></tr>

~~Description~~: ~~Crystal structure of Human GPR40 bound to allosteric agonist TAK~~-875

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phu RCSB], [http://www.ebi.ac.uk/pdbsum/4phu PDBsum]</td></tr>

<table>

__TOC__

</StructureSection>

[[Category: Lysozyme]]

[[Category: Aertgeerts, K.]]

[[Category: Gruswitz, F.]]

[[Category: Hirozane, Y.]]

[[Category: Ivetac, A.]]

[[Category: Jennings, A.]]

[[Category: Kefala, G.]]

[[Category: Lane, W.]]

[[Category: Nguyen, J.]]

[[Category: Okada, K.]]

[[Category: Snell, G.]]

[[Category: Srivastava, A.]]

[[Category: Yano, J K.]]

[[Category: Class some]]

[[Category: Fasiglifam]]

[[Category: Fatty acid binding protein]]

[[Category: Fatty acid binding protein-hydrolase complex]]

[[Category: G-protein coupled receptor]]

[[Category: Gpr40]]

[[Category: Tak-875]]

[[Category: Type ii diabetes]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of Human GPR40 bound to allosteric agonist TAK-875==
+<StructureSection load='4phu' size='340' side='right' caption='[[4phu]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
-The entry 4phu is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4phu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHU FirstGlance]. <br>
-Authors: Srivastava, A., Yano, J.K., Hirozane, Y., Kefala, G., Snell, G., Lane, W., Gruswitz, F., Ivetac, A., Aertgeerts, K., Nguyen, J., Jennings, A., Okada, K.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2YB:[(3S)-6-({2,6-DIMETHYL-4-[3-(METHYLSULFONYL)PROPOXY]BIPHENYL-3-YL}METHOXY)-2,3-DIHYDRO-1-BENZOFURAN-3-YL]ACETIC+ACID'>2YB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene><br>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-Description: Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phu RCSB], [http://www.ebi.ac.uk/pdbsum/4phu PDBsum]</span></td></tr>
+<table>
+__TOC__
+</StructureSection>
+[[Category: Lysozyme]]
+[[Category: Aertgeerts, K.]]
+[[Category: Gruswitz, F.]]
+[[Category: Hirozane, Y.]]
+[[Category: Ivetac, A.]]
+[[Category: Jennings, A.]]
+[[Category: Kefala, G.]]
+[[Category: Lane, W.]]
+[[Category: Nguyen, J.]]
+[[Category: Okada, K.]]
+[[Category: Snell, G.]]
+[[Category: Srivastava, A.]]
+[[Category: Yano, J K.]]
+[[Category: Class some]]
+[[Category: Fasiglifam]]
+[[Category: Fatty acid binding protein]]
+[[Category: Fatty acid binding protein-hydrolase complex]]
+[[Category: G-protein coupled receptor]]
+[[Category: Gpr40]]
+[[Category: Tak-875]]
+[[Category: Type ii diabetes]]