4l90: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l90]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L90 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4l90]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L90 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RL3:[5-(6-BROMO[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)-2,4-DIHYDROXYPHENYL](4-METHYLPIPERAZIN-1-YL)METHANONE'>RL3</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RL3:[5-(6-BROMO[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)-2,4-DIHYDROXYPHENYL](4-METHYLPIPERAZIN-1-YL)METHANONE'>RL3</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l8z|4l8z]], [[4l91|4l91]], [[4l93|4l93]], [[4l94|4l94]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l8z|4l8z]], [[4l91|4l91]], [[4l93|4l93]], [[4l94|4l94]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l90 RCSB], [http://www.ebi.ac.uk/pdbsum/4l90 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l90 RCSB], [http://www.ebi.ac.uk/pdbsum/4l90 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: He, J | [[Category: He, J]] | ||
[[Category: Li, J | [[Category: Li, J]] | ||
[[Category: Ren, J | [[Category: Ren, J]] | ||
[[Category: Xiong, B | [[Category: Xiong, B]] | ||
[[Category: Yang, M | [[Category: Yang, M]] | ||
[[Category: Atp hydrolysis]] | [[Category: Atp hydrolysis]] | ||
[[Category: Chaperone-chaperone inhibitor complex]] | [[Category: Chaperone-chaperone inhibitor complex]] | ||
[[Category: Hsp90n-hsp90n inhibitor complex]] | [[Category: Hsp90n-hsp90n inhibitor complex]] | ||
