Dual specificity phosphatase: Difference between revisions
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{{STRUCTURE_1ohe| PDB=1ohe | SIZE=400 | SCENE= |right|CAPTION=Human Cdc14B2 core domain complex with peptide (PDB code [[1ohe]]). }} | |||
__NOTOC__ | |||
'''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | |||
• Slingshot phosphatase<br /> | |||
• Phosphatase of regenerating liver<br /> | |||
• Cdc14<br /> | |||
• Cdc25<br /> | |||
• PTEN<br /> | |||
• Myotubularin<br /> | |||
• MAPK phosphatase see [[MAP kinase phosphatase]]<br /> | |||
==3D structures of dual specificity phosphatase== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
===slingshot phosphatase (SSH)=== | |||
[[2nt2]] – hSSH-2L catalytic domain - human<br /> | |||
===Phosphatase of regenerating liver (RPL)=== | |||
[[1xm2]] – hPRL-1 (mutant)<br /> | |||
[[1zck]], [[1x24]] – rPRL-1 - rat<br /> | |||
[[1zcl]] – rPRL-1 (mutant)<br /> | |||
[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br /> | |||
===Cdc14=== | |||
[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br /> | |||
[[1ohe]] – hCdc14B2 core domain + peptide<br /> | |||
===Cdc25=== | |||
[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br /> | |||
[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br /> | |||
===Phosphoinositide phosphatase PTEN=== | |||
[[1d5r]] – hPTEN (mutant)<br /> | |||
===Myotubularin-related protein (MTMR)=== | |||
[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br /> | |||
[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br /> | |||
[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br /> | |||
[[2yf0]] – hMTMR6<br /> | |||
===MAPK phosphatase=== | |||
[[MAP kinase phosphatase]] | |||
[[Category:Topic Page]] | |||
