4d1e: Difference between revisions

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'''~~Unreleased structure~~'''

==THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2==

~~The entry~~ 4d1e is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4d1e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1E FirstGlance]. <br>

~~Authors~~: ~~Pinotsis~~, N., ~~Salmazo~~, A., ~~Sjoeblom, B~~., Gkougkoulia, E., ~~Djinovic-Carugo~~, K.

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d1e RCSB], [http://www.ebi.ac.uk/pdbsum/4d1e PDBsum]</span></td></tr>

~~Description~~: ~~THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA~~-~~ACTININ~~-2

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[http://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>

== Function ==

[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

== References ==

__TOC__

</StructureSection>

[[Category: Djinovic-Carugo, K]]

[[Category: Gkougkoulia, E]]

[[Category: Pinotsis, N]]

[[Category: Salmazo, A]]

[[Category: Sjoeblom, B]]

[[Category: Abd]]

[[Category: Actin binding domain]]

[[Category: Calmodulin-like domain]]

[[Category: Contractile protein]]

[[Category: Spectrin domain]]

[[Category: Z-disc]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2==
+<StructureSection load='4d1e' size='340' side='right' caption='[[4d1e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-The entry 4d1e is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d1e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1E FirstGlance]. <br>
-Authors: Pinotsis, N., Salmazo, A., Sjoeblom, B., Gkougkoulia, E., Djinovic-Carugo, K.
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d1e RCSB], [http://www.ebi.ac.uk/pdbsum/4d1e PDBsum]</span></td></tr>
-Description: THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[http://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Djinovic-Carugo, K]]
+[[Category: Gkougkoulia, E]]
+[[Category: Pinotsis, N]]
+[[Category: Salmazo, A]]
+[[Category: Sjoeblom, B]]
+[[Category: Abd]]
+[[Category: Actin binding domain]]
+[[Category: Calmodulin-like domain]]
+[[Category: Contractile protein]]
+[[Category: Spectrin domain]]
+[[Category: Z-disc]]