Choline kinase: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckp). ' scene=''> == Function == '''Choli... |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code [[2ckp]]). ' scene=''> | <StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code [[2ckp]]). ' scene=''> | ||
| Line 17: | Line 16: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===Choline kinase=== | |||
[[2i7q]] – hCK α – human<br /> | [[2i7q]] – hCK α – human<br /> | ||
Revision as of 08:09, 26 August 2014
<StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckp). ' scene=>
Function
Choline kinase (CK) catalyzes the conversion of choline and ATP to phosphocholine and ADP. CK is part of phosphatidylcholine biosynthesis.
Disease
Overexpression of CK α1 was found in various types of cancer cells. This can aid in promoting cancer cells survival and growth. CK α1 is used as cancer biomarker and anticancer drug target.
Relevance
Structural highlights
3D structures of choline kinase
Updated on 26-August-2014
Choline kinase
2i7q – hCK α – human
2cko – hCK α2
Choline kinase complexes
2ckp – hCK α2 + ADP
2ckp – hCK α2 + phosphocholine
3zm9, 4da5, 4br3 – hCK α + inhibitor
3f2r – hCK α + hemicholinium-3
3g15 – hCK α + hemicholinium-3 + ADP
4cg8, 4cg9, 4cga – hCK α1 + bispyridinium derivative
