4bvc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BVC FirstGlance]. <br> | <table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BVC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bv5|4bv5]], [[4bv7|4bv7]], [[4bvd|4bvd]], [[4bvv|4bvv]], [[4bvw|4bvw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bv5|4bv5]], [[4bv7|4bv7]], [[4bvd|4bvd]], [[4bvv|4bvv]], [[4bvw|4bvw]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [http://www.ebi.ac.uk/pdbsum/4bvc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [http://www.ebi.ac.uk/pdbsum/4bvc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN]] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Althage, M | [[Category: Althage, M]] | ||
[[Category: Andersson, G M.K | [[Category: Andersson, G M.K]] | ||
[[Category: Antonsson, T | [[Category: Antonsson, T]] | ||
[[Category: Blaho, S | [[Category: Blaho, S]] | ||
[[Category: Bodin, C | [[Category: Bodin, C]] | ||
[[Category: Bostrom, J | [[Category: Bostrom, J]] | ||
[[Category: Chen, Y | [[Category: Chen, Y]] | ||
[[Category: Dahlen, A | [[Category: Dahlen, A]] | ||
[[Category: Eriksson, P O | [[Category: Eriksson, P O]] | ||
[[Category: Evertsson, E | [[Category: Evertsson, E]] | ||
[[Category: Fex, T | [[Category: Fex, T]] | ||
[[Category: Fjellstrom, O | [[Category: Fjellstrom, O]] | ||
[[Category: Gustafsson, D | [[Category: Gustafsson, D]] | ||
[[Category: Hallberg, C | [[Category: Hallberg, C]] | ||
[[Category: Hicks, R | [[Category: Hicks, R]] | ||
[[Category: Jarkvist, E | [[Category: Jarkvist, E]] | ||
[[Category: Johansson, C | [[Category: Johansson, C]] | ||
[[Category: Kalies, I | [[Category: Kalies, I]] | ||
[[Category: Kang, D | [[Category: Kang, D]] | ||
[[Category: Karlsson, B Svalstedt | [[Category: Karlsson, B Svalstedt]] | ||
[[Category: Kartberg, F | [[Category: Kartberg, F]] | ||
[[Category: Knecht, W | [[Category: Knecht, W]] | ||
[[Category: Legnehed, A | [[Category: Legnehed, A]] | ||
[[Category: Lindqvist, A M | [[Category: Lindqvist, A M]] | ||
[[Category: Martinsson, S A | [[Category: Martinsson, S A]] | ||
[[Category: Moberg, A | [[Category: Moberg, A]] | ||
[[Category: Petersson, A U | [[Category: Petersson, A U]] | ||
[[Category: Ridderstrom, M | [[Category: Ridderstrom, M]] | ||
[[Category: Sandmark, J | [[Category: Sandmark, J]] | ||
[[Category: Thelin, A | [[Category: Thelin, A]] | ||
[[Category: Tigerstrom, A | [[Category: Tigerstrom, A]] | ||
[[Category: Vinblad, J | [[Category: Vinblad, J]] | ||
[[Category: Xu, B | [[Category: Xu, B]] | ||
[[Category: Cardiovascular disease]] | [[Category: Cardiovascular disease]] | ||
[[Category: Drug discovery]] | [[Category: Drug discovery]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Optical biosensor]] | [[Category: Optical biosensor]] | ||
Revision as of 22:25, 24 December 2014
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Althage, M
- Andersson, G M.K
- Antonsson, T
- Blaho, S
- Bodin, C
- Bostrom, J
- Chen, Y
- Dahlen, A
- Eriksson, P O
- Evertsson, E
- Fex, T
- Fjellstrom, O
- Gustafsson, D
- Hallberg, C
- Hicks, R
- Jarkvist, E
- Johansson, C
- Kalies, I
- Kang, D
- Karlsson, B Svalstedt
- Kartberg, F
- Knecht, W
- Legnehed, A
- Lindqvist, A M
- Martinsson, S A
- Moberg, A
- Petersson, A U
- Ridderstrom, M
- Sandmark, J
- Thelin, A
- Tigerstrom, A
- Vinblad, J
- Xu, B
- Cardiovascular disease
- Drug discovery
- Hydrolase
- Optical biosensor
