4qte: Difference between revisions

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'''Unreleased structure'''
==Structure of ERK2 in complex with VTX-11e, 4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE==
 
<StructureSection load='4qte' size='340' side='right' caption='[[4qte]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
The entry 4qte is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4qte]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTE FirstGlance]. <br>
Authors: Chaikuad, A., Savitsky, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=390:4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE'>390</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
 
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qta|4qta]], [[4qtb|4qtb]], [[4qtc|4qtc]], [[4qtd|4qtd]]</td></tr>
Description: Structure of ERK2 in complex with VTX-11e, 4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qte OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qte RCSB], [http://www.ebi.ac.uk/pdbsum/4qte PDBsum]</span></td></tr>
<table>
__TOC__
</StructureSection>
[[Category: Mitogen-activated protein kinase]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Chaikuad, A.]]
[[Category: Delft, F von.]]
[[Category: Edwards, A M.]]
[[Category: Knapp, S.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Savitsky, P.]]
[[Category: Allosteric]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Mapk]]
[[Category: Sgc]]
[[Category: Signalling]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 08:14, 23 July 2014

Structure of ERK2 in complex with VTX-11e, 4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE

4qte, resolution 1.50Å

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