4txc: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor==

~~The entry~~ 4txc is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4txc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXC FirstGlance].

~~Authors~~: ~~Sorrell~~, F.J., ~~Krojer~~, T., ~~Wilbek~~, T.S., ~~Skovgaard, T~~., Berthelsen, J., ~~Dixon-Clark, S~~., Chalk, R.~~, Von~~ Delft, F., ~~Arrowsmith, C~~.~~H.,~~ Edwards, A.M., ~~Bountra~~, C., Stromgaard, K., ~~Knapp,~~ S.

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=38G:4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY)METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2-METHOXYPHENOL'>38G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[2yak|2yak]], [[4pf4|4pf4]]</td></tr>

~~Description~~: ~~Crystal Structure of DAPK1~~ kinase ~~domain in~~ complex ~~with a small~~ molecule ~~inhibitor~~

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txc RCSB], [http://www.ebi.ac.uk/pdbsum/4txc PDBsum]</td></tr>

<table>

__TOC__

</StructureSection>

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Arrowsmith, C H.]]

[[Category: Berthelsen, J.]]

[[Category: Bountra, C.]]

[[Category: Chalk, R.]]

[[Category: Delft, F Von.]]

[[Category: Dixon-Clarke, S.]]

[[Category: Edwards, A M.]]

[[Category: Knapp, S.]]

[[Category: Krojer, T.]]

[[Category: Skovgaard, T.]]

[[Category: Sorrell, F J.]]

[[Category: Stromgaard, K.]]

[[Category: Wilbek, T S.]]

[[Category: Catalytic domain]]

[[Category: Kinase]]

[[Category: Protein binding]]

[[Category: Protein kinase]]

[[Category: Protein kinase inhibitor]]

[[Category: Protein-ligand complex]]

[[Category: Small-molecule]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor==
+<StructureSection load='4txc' size='340' side='right' caption='[[4txc]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-The entry 4txc is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4txc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXC FirstGlance]. <br>
-Authors: Sorrell, F.J., Krojer, T., Wilbek, T.S., Skovgaard, T., Berthelsen, J., Dixon-Clark, S., Chalk, R., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Stromgaard, K., Knapp, S.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38G:4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY)METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2-METHOXYPHENOL'>38G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yak|2yak]], [[4pf4|4pf4]]</td></tr>
-Description: Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txc RCSB], [http://www.ebi.ac.uk/pdbsum/4txc PDBsum]</span></td></tr>
+<table>
+__TOC__
+</StructureSection>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Arrowsmith, C H.]]
+[[Category: Berthelsen, J.]]
+[[Category: Bountra, C.]]
+[[Category: Chalk, R.]]
+[[Category: Delft, F Von.]]
+[[Category: Dixon-Clarke, S.]]
+[[Category: Edwards, A M.]]
+[[Category: Knapp, S.]]
+[[Category: Krojer, T.]]
+[[Category: Skovgaard, T.]]
+[[Category: Sorrell, F J.]]
+[[Category: Stromgaard, K.]]
+[[Category: Wilbek, T S.]]
+[[Category: Catalytic domain]]
+[[Category: Kinase]]
+[[Category: Protein binding]]
+[[Category: Protein kinase]]
+[[Category: Protein kinase inhibitor]]
+[[Category: Protein-ligand complex]]
+[[Category: Small-molecule]]
+[[Category: Transferase]]