Cyclohydrolase: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*GTP cyclohydrolase I | |||
[[1gtp]] – EcGCH I – ''Escherichia coli''<br /> | **[[1gtp]] – EcGCH I – ''Escherichia coli''<br /> | ||
[[3d1t]] – NgGCH IB + Zn – ''Neisseria gonorrhoeae''<br /> | **[[3d1t]] – NgGCH IB + Zn – ''Neisseria gonorrhoeae''<br /> | ||
[[3d2o]] – NgGCH IB + Mn<br /> | **[[3d2o]] – NgGCH IB + Mn<br /> | ||
[[1fb1]] – hGCH I + Zn – human<br /> | **[[1fb1]] – hGCH I + Zn – human<br /> | ||
[[1wm9]] – TtGCH I + Zn – ''Thermus thermophilus''<br /> | **[[1wm9]] – TtGCH I + Zn – ''Thermus thermophilus''<br /> | ||
''GTP cyclohydrolase I complexes'' | *''GTP cyclohydrolase I complexes'' | ||
[[1a8r]], [[1a9c]], [[1n3r]], [[1n3t]], [[1n3s]] – EcGCH I (mutant) + GTP <br /> | **[[1a8r]], [[1a9c]], [[1n3r]], [[1n3t]], [[1n3s]] – EcGCH I (mutant) + GTP <br /> | ||
[[4du6]] – GCH I + GTP – ''Yersinia pseudotuberculosis''<br /> | **[[4du6]] – GCH I + GTP – ''Yersinia pseudotuberculosis''<br /> | ||
[[1fbx]] – EcGCH I + Zn <br /> | **[[1fbx]] – EcGCH I + Zn <br /> | ||
[[1wuq]], [[1wur]] – TtGCH I + Zn + 8-oxo-GTP <br /> | **[[1wuq]], [[1wur]] – TtGCH I + Zn + 8-oxo-GTP <br /> | ||
[[1is7]] – rGCH I + GCH feedback regulatory protein - rat<br /> | **[[1is7]] – rGCH I + GCH feedback regulatory protein - rat<br /> | ||
[[1is8]] – rGCH I + GCH feedback regulatory protein + Zn<br /> | **[[1is8]] – rGCH I + GCH feedback regulatory protein + Zn<br /> | ||
[[1wpl]] – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin<br /> | **[[1wpl]] – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin<br /> | ||
*GTP cyclohydrolase II | |||
[[2bz1]] – EcGCH II + Zn <br /> | **[[2bz1]] – EcGCH II + Zn <br /> | ||
[[2bz0]] – EcGCH II + Zn + phosphomethylphosphonic acid guanylate<br /> | **[[2bz0]] – EcGCH II + Zn + phosphomethylphosphonic acid guanylate<br /> | ||
*GTP cyclohydrolase III | |||
[[2qv6]] – GCH III + GTP + Ca – ''Methanocaldococcus jannaschii'' <br /> | **[[2qv6]] – GCH III + GTP + Ca – ''Methanocaldococcus jannaschii'' <br /> | ||
*IMP cyclohydrolase | |||
[[2ntm]] – MtICH – ''Methanothermobacter thermoautotrophicus''<br /> | **[[2ntm]] – MtICH – ''Methanothermobacter thermoautotrophicus''<br /> | ||
[[2ntk]] – MtICH + IMP <br /> | **[[2ntk]] – MtICH + IMP <br /> | ||
[[2ntl]] – MtICH + AICAR<br /> | **[[2ntl]] – MtICH + AICAR<br /> | ||
*Methenyltetrahydromethanopterin cyclohydrolase | |||
[[1qlm]] – MCH – ''Methanopyrus kandleri''<br /> | **[[1qlm]] – MCH – ''Methanopyrus kandleri''<br /> | ||
[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br /> | **[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br /> | ||
[[4gvq]] – AfMCH + tetrahydromethanopterin <br /> | **[[4gvq]] – AfMCH + tetrahydromethanopterin <br /> | ||
[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br /> | **[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br /> | ||
*Phosphoribosyl-ATP cyclohydrolase | |||
**[[1zps]] – MtPCH + Cd <br /> | |||
}} | |||
== References == | == References == | ||
Revision as of 11:55, 20 November 2014
<StructureSection load='1wuq' size='340' side='right' caption='Structure of GTP cyclohydrolase I pentamer complex with 8-oxo-GTP (stick model) and Zn+2 ion (grey) (PDB code 1wuq).' scene=>
Function
• GTP cyclohydrolase I catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis
• GTP cyclohydrolase II catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.
• IMP cyclohydrolase catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis
• Methenyltetrahydromethanopterin cyclohydrolase catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis
Disease
Relevance
Structural highlights
3D structures of cyclohydrolase
Updated on 20-November-2014
