4txc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4txc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXC FirstGlance]. <br> | <table><tr><td colspan='2'>[[4txc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38G:4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY)METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2-METHOXYPHENOL'>38G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38G:4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY)METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2-METHOXYPHENOL'>38G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yak|2yak]], [[4pf4|4pf4]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yak|2yak]], [[4pf4|4pf4]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txc RCSB], [http://www.ebi.ac.uk/pdbsum/4txc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txc RCSB], [http://www.ebi.ac.uk/pdbsum/4txc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia. | |||
Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1.,Wilbek TS, Skovgaard T, Sorrell FJ, Knapp S, Berthelsen J, Stromgaard K Chembiochem. 2014 Nov 7. doi: 10.1002/cbic.201402512. PMID:25382253<ref>PMID:25382253</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Berthelsen, J | [[Category: Berthelsen, J]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Chalk, R | [[Category: Chalk, R]] | ||
[[Category: Delft, F Von | [[Category: Delft, F Von]] | ||
[[Category: Dixon-Clarke, S | [[Category: Dixon-Clarke, S]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Knapp, S | [[Category: Knapp, S]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Skovgaard, T | [[Category: Skovgaard, T]] | ||
[[Category: Sorrell, F J | [[Category: Sorrell, F J]] | ||
[[Category: Stromgaard, K | [[Category: Stromgaard, K]] | ||
[[Category: Wilbek, T S | [[Category: Wilbek, T S]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
