3j6j: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3j6j]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6J FirstGlance]. <br> | <table><tr><td colspan='2'>[[3j6j]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6J FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6j RCSB], [http://www.ebi.ac.uk/pdbsum/3j6j PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6j RCSB], [http://www.ebi.ac.uk/pdbsum/3j6j PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN]] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Egelman, E | [[Category: Egelman, E]] | ||
[[Category: Hur, S | [[Category: Hur, S]] | ||
[[Category: Li, Z | [[Category: Li, Z]] | ||
[[Category: Peisley, A | [[Category: Peisley, A]] | ||
[[Category: Penczek, P | [[Category: Penczek, P]] | ||
[[Category: Walz, T | [[Category: Walz, T]] | ||
[[Category: Wu, B | [[Category: Wu, B]] | ||
[[Category: Card]] | [[Category: Card]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
