1d5v: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 7: Line 7:
|ACTIVITY=  
|ACTIVITY=  
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5v OCA], [http://www.ebi.ac.uk/pdbsum/1d5v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d5v RCSB]</span>
}}
}}


Line 14: Line 17:
==Overview==
==Overview==
Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.
Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.
==Disease==
Known diseases associated with this structure: Lymphedema and ptosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Lymphedema, hereditary II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Lymphedema-distichiasis syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Lymphedema-distichiasis syndrome with renal disease and diabetes mellitus OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Yellow nail syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]]


==About this Structure==
==About this Structure==
Line 33: Line 33:
[[Category: winged helix]]
[[Category: winged helix]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:33:16 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:35:12 2008''
Retrieved from "https://proteopedia.org/1d5v"