2mny: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mny]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNY FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mny]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNY FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mnz|2mnz]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mnz|2mnz]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mny RCSB], [http://www.ebi.ac.uk/pdbsum/2mny PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mny RCSB], [http://www.ebi.ac.uk/pdbsum/2mny PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Cao, C | [[Category: Cao, C]] | ||
[[Category: Guo, X | [[Category: Guo, X]] | ||
[[Category: Lan, W X | [[Category: Lan, W X]] | ||
[[Category: Rong, N Y | [[Category: Rong, N Y]] | ||
[[Category: Song, Y J | [[Category: Song, Y J]] | ||
[[Category: Xu, Y H | [[Category: Xu, Y H]] | ||
[[Category: Xu, Y W | [[Category: Xu, Y W]] | ||
[[Category: Yang, H R | [[Category: Yang, H R]] | ||
[[Category: Zhang, Y | [[Category: Zhang, Y]] | ||
[[Category: Demethylation]] | [[Category: Demethylation]] | ||
[[Category: H3k4]] | [[Category: H3k4]] | ||
