4ow1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ow1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OW1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ow1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OW1 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ow1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ow1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ow1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ow1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ow1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ow1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ow1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ow1 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RPFC_MYCTU RPFC_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Chauviac, F X | [[Category: Chauviac, F X]] | ||
[[Category: Cohen-Gonsaud, M | [[Category: Cohen-Gonsaud, M]] | ||
[[Category: Keep, N H | [[Category: Keep, N H]] | ||
[[Category: Quay, D H.X | [[Category: Quay, D H.X]] | ||
[[Category: Peptidoglycan]] | [[Category: Peptidoglycan]] | ||
[[Category: Resuscitation promoting factor]] | [[Category: Resuscitation promoting factor]] | ||
[[Category: Transglycosylase]] | [[Category: Transglycosylase]] | ||
Revision as of 17:11, 24 December 2014
Crystal Structure of Resuscitation Promoting Factor C
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