4qxf: Difference between revisions
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''' | ==crystal structure of human LGR4 and Rspo1== | ||
<StructureSection load='4qxf' size='340' side='right' caption='[[4qxf]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
The entry | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qxf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QXF FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qxf RCSB], [http://www.ebi.ac.uk/pdbsum/4qxf PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma. Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:[http://omim.org/entry/610644 610644]]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LGR4_HUMAN LGR4_HUMAN]] Orphan receptor. [[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.<ref>PMID:16109882</ref> <ref>PMID:22575959</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Huang, C.]] | |||
[[Category: Xu, J G.]] | |||
[[Category: Zhou, Y.]] | |||
[[Category: Zhu, Y.]] | |||
[[Category: Beta-hairpin]] | |||
[[Category: Cell membrane]] | |||
[[Category: Glucosylation]] | |||
[[Category: Ligand-receptor complex]] | |||
[[Category: Lrr repeat]] | |||
[[Category: Membrane protein]] | |||
Revision as of 07:53, 8 October 2014
crystal structure of human LGR4 and Rspo1
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