4u6v: Difference between revisions
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''' | ==Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody== | ||
<StructureSection load='4u6v' size='340' side='right' caption='[[4u6v]], [[Resolution|resolution]] 2.56Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4u6v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6V FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6v RCSB], [http://www.ebi.ac.uk/pdbsum/4u6v PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
MEDI4893 is a neutralizing human monoclonal antibody that targets alpha toxin (AT), and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a resolution of 2.56 A, and further characterized its epitope using various engineered AT variants. We have found that MEDI4893 recognizes a novel epitope in AT so-called rim domain, and exerts its neutralizing effect through a dual mechanism. More particularly, MEDI4893 not only sterically blocks binding of AT to its cell receptor, but also prevents it from adopting a lytic heptameric trans-membrane conformation. | |||
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody.,Oganesyan V, Peng L, Damschroder MM, Cheng L, Sadowska A, Tkaczyk C, Sellman BR, Wu H, Dall'Acqua WF J Biol Chem. 2014 Sep 10. pii: jbc.M114.601328. PMID:25210036<ref>PMID:25210036</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Acqua, W F.Dall.]] | |||
[[Category: Cheng, L.]] | |||
[[Category: Damschroder, M M.]] | |||
[[Category: Oganesyan, V Y.]] | |||
[[Category: Peng, L.]] | |||
[[Category: Sadowska, A.]] | |||
[[Category: Sellman, B.]] | |||
[[Category: Tkaczyk, C.]] | |||
[[Category: Wu, H.]] | |||
[[Category: Alpha toxin]] | |||
[[Category: Fab]] | |||
[[Category: Immune system]] | |||
[[Category: Mutagenesis]] | |||
[[Category: Staphylococcus aureus]] | |||
Revision as of 06:43, 24 September 2014
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
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