1dj0: Difference between revisions
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|PDB= 1dj0 |SIZE=350|CAPTION= <scene name='initialview01'>1dj0</scene>, resolution 1.50Å | |PDB= 1dj0 |SIZE=350|CAPTION= <scene name='initialview01'>1dj0</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dj0 OCA], [http://www.ebi.ac.uk/pdbsum/1dj0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dj0 RCSB]</span> | |||
}} | }} | ||
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[[Category: Santi, D V.]] | [[Category: Santi, D V.]] | ||
[[Category: Stroud, R M.]] | [[Category: Stroud, R M.]] | ||
[[Category: alpha/beta fold]] | [[Category: alpha/beta fold]] | ||
[[Category: rna-binding motif]] | [[Category: rna-binding motif]] | ||
[[Category: rna-modifying enzyme]] | [[Category: rna-modifying enzyme]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:42:26 2008'' | ||
Revision as of 16:42, 30 March 2008
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| 1dj0, resolution 1.50Å | |||||||||||||
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| Ligands: | CL | ||||||||||||
| Activity: | Pseudouridylate synthase, with EC number 4.2.1.70 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION
Overview
Pseudouridine synthases catalyze the isomerization of specific uridines to pseudouridine in a variety of RNAs, yet the basis for recognition of the RNA sites or how they catalyze this reaction is unknown. The crystal structure of pseudouridine synthase I from Escherichia coli, which, for example, modifies positions 38, 39 and/or 40 in tRNA, reveals a dimeric protein that contains two positively charged, RNA-binding clefts along the surface of the protein. Each cleft contains a highly conserved aspartic acid located at its center. The structural domains have a topological similarity to those of other RNA-binding proteins, though the mode of interaction with tRNA appears to be unique. The structure suggests that a dimeric enzyme is required for binding transfer RNA and subsequent pseudouridine formation.
About this Structure
1DJ0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I., Foster PG, Huang L, Santi DV, Stroud RM, Nat Struct Biol. 2000 Jan;7(1):23-7. PMID:10625422
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