Adaptin

<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (grey), AP-β-1 (light green), AP-μ-1 (green), AP-σ-1 (olive green) complex with inositole hexakisphosphate (PDB entry 2vgl)' scene=> Adaptin (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.

3D structures of adaptin

Updated on 12-November-2014

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• AP-α-2
  • 1b9x, 1qts – mAP appendage domain – mouse
    
  • 1qtp – mAP appendage domain (mutant)
    
  • 1ky6, 1kyd – mAP appendage domain + epsin peptide
    
  • 1ky7 – mAP appendage domain + amphiphysin peptide
    
  • 1kyf, 1kyu – mAP appendage domain + eps15 peptide
    
  • 1w80, 2vj0 – mAP appendage domain + synaptojanin peptide
    
  • 3hs8 – mAP appendage domain + intersectin peptide
    
• AP-β
  • 1e42 – hAP-1 appendage domain - human
    
  • 2g30 – hAP-1 appendage domain + ARH peptide
    
  • 3h1z – hAP-1 appendage domain + PTDINSPKI-γ peptide
    
  • 3hs9 – hAP-1 appendage domain + intersectin peptide
    
  • 2iv9 – hAP-2 appendage domain + eps15 peptide
    
  • 2iv8 – hAP-2 appendage domain + B-arrestin peptide
    
• AP-γ
  • 1iu1 – hAP-1 ear domain
    
  • 1gyu, 2a7b – mAP-1 appendage domain
    
  • 1gyv, 1gyw, 3zy7 – mAP-1 appendage domain (mutant)
    
  • 2e9g, 4bcx – hAP-2 ear domain
    
  • 2ymt – hAP-2 ear domain + peptide
    
  • 3zhf – hAP-2 ear domain + large envelope protein peptide
    
• AP-δ-1
  • 4afi – hAP-1/vesicle-associated membrane protein 7
    
• AP-μ
  • 3h85 – rAP-1 appendage domain + PTDINSPKIγ peptide
    
  • 4emz, 4en2 – mAP-1 sorting motif recognition domain + nef + MHC-I
    
  • 1bw8, 1i31 – rAP-2 + EGFR peptide
    
  • 1bxx – rAP-2 + TGN38 peptide
    
  • 1hes – rAP-2 + selectin peptide
    
  • 2bp5 – rAP-2 + purinoceptor peptide
    
  • 2pr9 – rAP-2 + GABA receptor peptide
    
• AP-α + AP-β + AP-μ + AP-σ
  • 2vgl – rAPα-2 + APβ-1 + APμ-1 + APσ-1
    
  • 2jkr, 2jkt – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide
    
  • 2xa7 – rAPα-2 + APβ + APμ + APσ + cargo peptide
    
• AP-γ + AP-β + AP-μ + AP-σ
  • 1w63 – mAPγ-1 + APβ-1 + APμ-1 + APσ-1A
    
  • 4hmy – mAPγ-1 + APβ-1 + APμ-1 + APσ-3 + ADP-ribosylation factor
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky