Nitric Oxide Synthase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2g6h| PDB=2g6h | SIZE=400| SCENE=Nitric_oxide_synthase/Nos/1 |right|CAPTION=Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn+2 (grey), [[2g6h]] }} | {{STRUCTURE_2g6h| PDB=2g6h | SIZE=400| SCENE=Nitric_oxide_synthase/Nos/1 |right|CAPTION=Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn+2 (grey), [[2g6h]] }} | ||
| Line 93: | Line 92: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Endothelial NOS | |||
[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br /> | **[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br /> | ||
[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | **[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | ||
[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br /> | **[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br /> | ||
[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | **[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | ||
[[1nse]] – b-eNOS OD<br /> | **[[1nse]] – b-eNOS OD<br /> | ||
[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | **[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | ||
[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br /> | **[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br /> | ||
[[6nse]] – b-eNOS OD+canavanine<br /> | **[[6nse]] – b-eNOS OD+canavanine<br /> | ||
[[7nse]] – b-eNOS OD+ADMA<br /> | **[[7nse]] – b-eNOS OD+ADMA<br /> | ||
[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br /> | **[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br /> | ||
[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br /> | **[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br /> | ||
[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]] – b-eNOS OD+inhibitor<br /> | **[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]] – b-eNOS OD+inhibitor<br /> | ||
[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative<br /> | **[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative<br /> | ||
[[1dm8]] – b-eNOS OD+triazole derivative<br /> | **[[1dm8]] – b-eNOS OD+triazole derivative<br /> | ||
[[1ed6]] – b-eNOS OD+NO<br /> | **[[1ed6]] – b-eNOS OD+NO<br /> | ||
[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br /> | **[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br /> | ||
[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor - rat<br /> | **[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor - rat<br /> | ||
[[3nli]] - r-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br /> | **[[3nli]] - r-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br /> | ||
[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]] – r-eNOS OD+ pyridine derivative<br /> | **[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]] – r-eNOS OD+ pyridine derivative<br /> | ||
[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br /> | **[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br /> | ||
[[3eah]] – h-eNOS OD - human<br /> | **[[3eah]] – h-eNOS OD - human<br /> | ||
[[3nos]] – h-eNOS OD+arginine<br /> | **[[3nos]] – h-eNOS OD+arginine<br /> | ||
[[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | **[[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | ||
[[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br /> | **[[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br /> | ||
[[1nsi]] - h-eNOS OD+ Zn | **[[1nsi]] - h-eNOS OD+ Zn | ||
*Neuronal NOS | |||
[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br /> | **[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br /> | ||
[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]] - b-nNOS OD + inhibitor<br /> | **[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]] - b-nNOS OD + inhibitor<br /> | ||
[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] - r-nNOS OD (mutant)+ pyridine derivative – rat<br /> | **[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] - r-nNOS OD (mutant)+ pyridine derivative – rat<br /> | ||
[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] - r-nNOS OD+ pyridine derivative<br /> | **[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] - r-nNOS OD+ pyridine derivative<br /> | ||
[[4gqe]] – r-nNOS OD + norvaline derivative<br /> | **[[4gqe]] – r-nNOS OD + norvaline derivative<br /> | ||
[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative<br /> | **[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative<br /> | ||
[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]] – r-nNOS OD heme domain + quinoline derivative<br /> | **[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]] – r-nNOS OD heme domain + quinoline derivative<br /> | ||
[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br /> | **[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br /> | ||
[[1om5]] – r-nNOS OD+indazole derivative<br /> | **[[1om5]] – r-nNOS OD+indazole derivative<br /> | ||
[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine derivative<br /> | **[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine derivative<br /> | ||
[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS OD heme domain +thiophene carboximidamide derivative<br /> | **[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS OD heme domain +thiophene carboximidamide derivative<br /> | ||
[[3fc5]], [[1zvi]] – r-nNOS OD<br /> | **[[3fc5]], [[1zvi]] – r-nNOS OD<br /> | ||
[[1qau]] - r-nNOS OD PDZ domain<br /> | **[[1qau]] - r-nNOS OD PDZ domain<br /> | ||
[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br /> | **[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br /> | ||
[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]] – r-nNOS OD+inhibitor<br /> | **[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]] – r-nNOS OD+inhibitor<br /> | ||
[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br /> | **[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br /> | ||
[[3hsn]] – r-nNOS OD+NHA+CO<br /> | **[[3hsn]] – r-nNOS OD+NHA+CO<br /> | ||
[[3hso]], [[3hsp]] - r-nNOS OD+NHA+NO<br /> | **[[3hso]], [[3hsp]] - r-nNOS OD+NHA+NO<br /> | ||
[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br /> | **[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br /> | ||
[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br /> | **[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br /> | ||
[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO<br /> | **[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO<br /> | ||
[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br /> | **[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br /> | ||
[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br /> | **[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br /> | ||
[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br /> | **[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br /> | ||
[[1f20]] - r-nNOS FAD/NADP domain<br /> | **[[1f20]] - r-nNOS FAD/NADP domain<br /> | ||
[[1vag]] – m-nNOS OD+inhibitor - mouse<br /> | **[[1vag]] – m-nNOS OD+inhibitor - mouse<br /> | ||
*Inducible NOS | |||
[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative<br /> | **[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative<br /> | ||
[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | **[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | ||
[[2bhj]] – m-iNOS OD+coumarin<br /> | **[[2bhj]] – m-iNOS OD+coumarin<br /> | ||
[[3nod]] – m-iNOS OD+product analog<br /> | **[[3nod]] – m-iNOS OD+product analog<br /> | ||
[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br /> | **[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br /> | ||
[[3e67]] – m-iNOS OD+4-MAP<br /> | **[[3e67]] – m-iNOS OD+4-MAP<br /> | ||
[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br /> | **[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br /> | ||
[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br /> | **[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br /> | ||
[[1df1]] - m-iNOS OD+ urea derivative<br /> | **[[1df1]] - m-iNOS OD+ urea derivative<br /> | ||
[[3dwj]] – m-iNOS OD (mutant)<br /> | **[[3dwj]] – m-iNOS OD (mutant)<br /> | ||
[[1qom]] - m-iNOS OD<br /> | **[[1qom]] - m-iNOS OD<br /> | ||
[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br /> | **[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br /> | ||
[[2nos]] – m-iNOS OD+guanidine derivative<br /> | **[[2nos]] – m-iNOS OD+guanidine derivative<br /> | ||
[[1n2n]] – m-iNOS OD+CN<br /> | **[[1n2n]] – m-iNOS OD+CN<br /> | ||
[[1m9t]] – m-iNOS OD+indazole derivative<br /> | **[[1m9t]] – m-iNOS OD+indazole derivative<br /> | ||
[[1m8d]] – m-iNOS OD+chlorzoxazone<br /> | **[[1m8d]] – m-iNOS OD+chlorzoxazone<br /> | ||
[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br /> | **[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br /> | ||
[[1jwj]] – m-iNOS OD + inhibitor<br /> | **[[1jwj]] – m-iNOS OD + inhibitor<br /> | ||
[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br /> | **[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br /> | ||
[[3hr4]] – h-iNOS residues 503-715+calmodulin – human<br /> | **[[3hr4]] – h-iNOS residues 503-715+calmodulin – human<br /> | ||
[[3e7g]] – h-iNOS residues 82-505+inhibitor<br /> | **[[3e7g]] – h-iNOS residues 82-505+inhibitor<br /> | ||
[[3ej8]] – h-iNOS OD+imidazole<br /> | **[[3ej8]] – h-iNOS OD+imidazole<br /> | ||
[[4nos]] – h-iNOS OD+inhibitor<br /> | **[[4nos]] – h-iNOS OD+inhibitor<br /> | ||
[[1nsi]] – h-iNOS OD+arginine<br /> | **[[1nsi]] – h-iNOS OD+arginine<br /> | ||
[[2nsi]] – h-iNOS OD+thiourea derivative<br /> | **[[2nsi]] – h-iNOS OD+thiourea derivative<br /> | ||
[[3gof]] - c-iNOS OD + calmodulin – chicken<br /> | **[[3gof]] - c-iNOS OD + calmodulin – chicken<br /> | ||
*Prokaryote NOS | |||
**[[2amo]] – BsNOS – ''Bacillus subtilis''<br /> | |||
**[[2an0]], [[2an2]] – BsNOS (mutant)<br /> | |||
**[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br /> | |||
**[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br /> | |||
**[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus''<br /> | |||
}} | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||