Nitric Oxide Synthase: Difference between revisions

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{{STRUCTURE_2g6h|  PDB=2g6h  | SIZE=400| SCENE=Nitric_oxide_synthase/Nos/1 |right|CAPTION=Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn+2 (grey), [[2g6h]] }}
{{STRUCTURE_2g6h|  PDB=2g6h  | SIZE=400| SCENE=Nitric_oxide_synthase/Nos/1 |right|CAPTION=Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn+2 (grey), [[2g6h]] }}


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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===Endothelial NOS===
*Endothelial NOS


[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br />
**[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br />
[[1dm6]] – b-eNOS OD+guanidine derivative<br />
**[[1dm6]] – b-eNOS OD+guanidine derivative<br />
[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />
**[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />
[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
**[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
[[1nse]] – b-eNOS OD<br />
**[[1nse]] – b-eNOS OD<br />
[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
**[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br />
**[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br />
[[6nse]] – b-eNOS OD+canavanine<br />
**[[6nse]] – b-eNOS OD+canavanine<br />
[[7nse]] – b-eNOS OD+ADMA<br />
**[[7nse]] – b-eNOS OD+ADMA<br />
[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br />
**[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br />
[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br />
**[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br />
[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]] – b-eNOS OD+inhibitor<br />
**[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]] – b-eNOS OD+inhibitor<br />
[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative<br />
**[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative<br />
[[1dm8]] – b-eNOS OD+triazole derivative<br />
**[[1dm8]] – b-eNOS OD+triazole derivative<br />
[[1ed6]] – b-eNOS OD+NO<br />
**[[1ed6]] – b-eNOS OD+NO<br />
[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br />
**[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br />
[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor - rat<br />
**[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor - rat<br />
[[3nli]] - r-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />  
**[[3nli]] - r-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />  
[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]] – r-eNOS OD+ pyridine derivative<br />
**[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]] – r-eNOS OD+ pyridine derivative<br />
[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br />
**[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br />
[[3eah]] – h-eNOS OD - human<br />
**[[3eah]] – h-eNOS OD - human<br />
[[3nos]] – h-eNOS OD+arginine<br />
**[[3nos]] – h-eNOS OD+arginine<br />
[[1m9j]] – h-eNOS OD+chlorzoxazone<br />
**[[1m9j]] – h-eNOS OD+chlorzoxazone<br />
[[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br />
**[[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br />
[[1nsi]] - h-eNOS OD+ Zn
**[[1nsi]] - h-eNOS OD+ Zn


===Neuronal NOS===
*Neuronal NOS


[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br />
**[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br />
[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]] - b-nNOS OD + inhibitor<br />
**[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]] - b-nNOS OD + inhibitor<br />
[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] - r-nNOS OD (mutant)+ pyridine derivative – rat<br />
**[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] - r-nNOS OD (mutant)+ pyridine derivative – rat<br />
[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] - r-nNOS OD+ pyridine derivative<br />
**[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] - r-nNOS OD+ pyridine derivative<br />
[[4gqe]]  – r-nNOS OD + norvaline derivative<br />
**[[4gqe]]  – r-nNOS OD + norvaline derivative<br />
[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative<br />
**[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative<br />
[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]]  – r-nNOS OD heme domain + quinoline derivative<br />
**[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]]  – r-nNOS OD heme domain + quinoline derivative<br />
[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br />
**[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br />
[[1om5]] – r-nNOS OD+indazole derivative<br />
**[[1om5]] – r-nNOS OD+indazole derivative<br />
[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine derivative<br />
**[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine derivative<br />
[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS OD heme domain +thiophene carboximidamide derivative<br />
**[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS OD heme domain +thiophene carboximidamide derivative<br />
[[3fc5]], [[1zvi]] – r-nNOS OD<br />
**[[3fc5]], [[1zvi]] – r-nNOS OD<br />
[[1qau]] - r-nNOS OD PDZ domain<br />
**[[1qau]] - r-nNOS OD PDZ domain<br />
[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br />
**[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br />
[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]] – r-nNOS OD+inhibitor<br />
**[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]] – r-nNOS OD+inhibitor<br />
[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br />
**[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br />
[[3hsn]] – r-nNOS OD+NHA+CO<br />
**[[3hsn]] – r-nNOS OD+NHA+CO<br />
[[3hso]], [[3hsp]] -  r-nNOS OD+NHA+NO<br />
**[[3hso]], [[3hsp]] -  r-nNOS OD+NHA+NO<br />
[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br />
**[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br />
[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br />
**[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br />
[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO<br />
**[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO<br />
[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br />
**[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br />
[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br />
**[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br />
[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br />
**[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br />
[[1f20]] - r-nNOS FAD/NADP domain<br />
**[[1f20]] - r-nNOS FAD/NADP domain<br />
[[1vag]] – m-nNOS OD+inhibitor - mouse<br />
**[[1vag]] – m-nNOS OD+inhibitor - mouse<br />


===Inducible NOS===
*Inducible NOS
   
   
[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]]  – m-iNOS OD + pterin derivative<br />  
**[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]]  – m-iNOS OD + pterin derivative<br />  
[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br />
**[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br />
[[2bhj]] – m-iNOS OD+coumarin<br />
**[[2bhj]] – m-iNOS OD+coumarin<br />
[[3nod]] – m-iNOS OD+product analog<br />
**[[3nod]] – m-iNOS OD+product analog<br />
[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br />
**[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br />
[[3e67]] – m-iNOS OD+4-MAP<br />
**[[3e67]] – m-iNOS OD+4-MAP<br />
[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br />
**[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br />
[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br />
**[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br />
[[1df1]] - m-iNOS OD+ urea derivative<br />
**[[1df1]] - m-iNOS OD+ urea derivative<br />
[[3dwj]] – m-iNOS OD (mutant)<br />
**[[3dwj]] – m-iNOS OD (mutant)<br />
[[1qom]] - m-iNOS OD<br />
**[[1qom]] - m-iNOS OD<br />
[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br />
**[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br />
[[2nos]] – m-iNOS OD+guanidine derivative<br />
**[[2nos]] – m-iNOS OD+guanidine derivative<br />
[[1n2n]] – m-iNOS OD+CN<br />
**[[1n2n]] – m-iNOS OD+CN<br />
[[1m9t]] – m-iNOS OD+indazole derivative<br />
**[[1m9t]] – m-iNOS OD+indazole derivative<br />
[[1m8d]] – m-iNOS OD+chlorzoxazone<br />
**[[1m8d]] – m-iNOS OD+chlorzoxazone<br />
[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br />
**[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br />
[[1jwj]] – m-iNOS OD + inhibitor<br />  
**[[1jwj]] – m-iNOS OD + inhibitor<br />  
[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br />
**[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br />
[[3hr4]] – h-iNOS residues 503-715+calmodulin – human<br />
**[[3hr4]] – h-iNOS residues 503-715+calmodulin – human<br />
[[3e7g]] – h-iNOS residues 82-505+inhibitor<br />
**[[3e7g]] – h-iNOS residues 82-505+inhibitor<br />
[[3ej8]] – h-iNOS OD+imidazole<br />
**[[3ej8]] – h-iNOS OD+imidazole<br />
[[4nos]] – h-iNOS OD+inhibitor<br />
**[[4nos]] – h-iNOS OD+inhibitor<br />
[[1nsi]] – h-iNOS OD+arginine<br />
**[[1nsi]] – h-iNOS OD+arginine<br />
[[2nsi]] – h-iNOS OD+thiourea derivative<br />
**[[2nsi]] – h-iNOS OD+thiourea derivative<br />
[[3gof]] - c-iNOS OD + calmodulin – chicken<br />
**[[3gof]] - c-iNOS OD + calmodulin – chicken<br />
 
===Prokaryote NOS===


[[2amo]] – BsNOS – ''Bacillus subtilis''<br />
*Prokaryote NOS
[[2an0]], [[2an2]] – BsNOS (mutant)<br />
[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br />
[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br />
[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus''<br />


**[[2amo]] – BsNOS – ''Bacillus subtilis''<br />
**[[2an0]], [[2an2]] – BsNOS (mutant)<br />
**[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br />
**[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br />
**[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus''<br />
}}
==References==
==References==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]