4pno: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Escherichia coli Hfq-RNA complex at 0.97 A Resolution==

== Structural highlights ==

<table><tr><td colspan='2'>[[4pno]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNO FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pno OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pno RCSB], [http://www.ebi.ac.uk/pdbsum/4pno PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

In bacteria, small RNAs (sRNAs) silence or activate target genes through base pairing with the mRNA, thereby modulating its translation. A central player in this process is the RNA chaperone Hfq, which facilitates the annealing of sRNAs with their target mRNAs. Hfq has two RNA-binding surfaces that recognize A-rich and U-rich sequences, and is believed to bind an sRNA-mRNA pair simultaneously. However, how Hfq promotes annealing remains unclear. Here, the crystal structure of Escherichia coli Hfq is presented in complex with U6-RNA bound to its proximal binding site at 0.97 A resolution, revealing the Hfq-RNA interaction in exceptional detail.

~~The entry 4pno is ON HOLD~~

Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.,Schulz EC, Barabas O Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1492-7. doi:, 10.1107/S2053230X14020044. Epub 2014 Oct 31. PMID:25372815<ref>PMID:25372815</ref>

~~Authors: Schulz~~, E.C., Barabas, O.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: ~~Escherichia coli Hfq-RNA complex at 0.97 A Resolution~~

== References ==

__TOC__

</StructureSection>

[[Category: Barabas, O]]

[[Category: Schulz, E C]]

[[Category: Rna binding protein]]

[[Category: Rna chaperone hfq rna lsm]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Escherichia coli Hfq-RNA complex at 0.97 A Resolution==
+<StructureSection load='4pno' size='340' side='right' caption='[[4pno]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4pno]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNO FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pno OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pno RCSB], [http://www.ebi.ac.uk/pdbsum/4pno PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In bacteria, small RNAs (sRNAs) silence or activate target genes through base pairing with the mRNA, thereby modulating its translation. A central player in this process is the RNA chaperone Hfq, which facilitates the annealing of sRNAs with their target mRNAs. Hfq has two RNA-binding surfaces that recognize A-rich and U-rich sequences, and is believed to bind an sRNA-mRNA pair simultaneously. However, how Hfq promotes annealing remains unclear. Here, the crystal structure of Escherichia coli Hfq is presented in complex with U6-RNA bound to its proximal binding site at 0.97 A resolution, revealing the Hfq-RNA interaction in exceptional detail.
-The entry 4pno is ON HOLD
+Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.,Schulz EC, Barabas O Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1492-7. doi:, 10.1107/S2053230X14020044. Epub 2014 Oct 31. PMID:25372815<ref>PMID:25372815</ref>
-Authors: Schulz, E.C., Barabas, O.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Escherichia coli Hfq-RNA complex at 0.97 A Resolution
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Barabas, O]]
+[[Category: Schulz, E C]]
+[[Category: Rna binding protein]]
+[[Category: Rna chaperone hfq rna lsm]]