4u6y: Difference between revisions

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'''~~Unreleased~~ structure'''

==Crystal Structure of HLA-A*0201 in complex with FLNDK, a 15 mer self-peptide==

The ~~entry 4u6y~~ is ~~ON HOLD~~ ~~until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4u6y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6Y OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6Y FirstGlance].

~~Authors~~: ~~Gras, S~~., Chabrol, E., Rossjohn, J.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4u6x|4u6x]]</td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6y RCSB], [http://www.ebi.ac.uk/pdbsum/4u6y PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

== Function ==

[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

== References ==

__TOC__

</StructureSection>

[[Category: Chabrol, E]]

[[Category: Gras, S]]

[[Category: Rossjohn, J]]

[[Category: Hla a*0201]]

[[Category: Immune system]]

[[Category: Ligandome]]

[[Category: T cell]]

[[Category: Tcr]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of HLA-A*0201 in complex with FLNDK, a 15 mer self-peptide==
+<StructureSection load='4u6y' size='340' side='right' caption='[[4u6y]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
-The entry 4u6y is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4u6y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6Y FirstGlance]. <br>
-Authors: Gras, S., Chabrol, E., Rossjohn, J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u6x|4u6x]]</td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6y RCSB], [http://www.ebi.ac.uk/pdbsum/4u6y PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chabrol, E]]
+[[Category: Gras, S]]
+[[Category: Rossjohn, J]]
+[[Category: Hla a*0201]]
+[[Category: Immune system]]
+[[Category: Ligandome]]
+[[Category: T cell]]
+[[Category: Tcr]]