Fibrin: Difference between revisions
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{{STRUCTURE_1n73| PDB=1n73 | SIZE= | {{STRUCTURE_1n73| PDB=1n73 | SIZE=350| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin α1 subunit (red, yellow), β subunit (Green, blue), γ subunit (orange, magenta) from ''Petromyzon marinus'', [[1n73]] }} | ||
== Function == | |||
[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). | [[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa)<ref>PMID:12501189</ref>. | ||
== Disease == | |||
Overexpression of FIa can cause thrombosis. | |||
== 3D Structures of Fibrin == | == 3D Structures of Fibrin == | ||
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[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br /> | [[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br /> | ||
[[1fzc]] – hDDFIa+peptide<br /> | [[1fzc]] – hDDFIa+peptide<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 20:34, 21 January 2016
Function
Fibrin (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa)[1].
Disease
Overexpression of FIa can cause thrombosis.
3D Structures of Fibrin
Updated on 21-January-2016
3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
1n73 - FIa α, β, γ chains + peptide – Sea lamprey
1fzc – hDDFIa+peptide
