Hyaluronidase: Difference between revisions

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|[[Image:Hyal reaction.jpg|thumb|right|'''Hyaluronidase cleaves the β1,4-glycosidic bond of the glycosaminoglycan hyaluronan''' |400px]]
|[[Image:Hyal reaction.jpg|thumb|right|'''Hyaluronidase cleaves the β1,4-glycosidic bond of the glycosaminoglycan hyaluronan''' |400px]]
|}
|}
 
</StructureSection>


==3D structures of hyaluronidase==
==3D structures of hyaluronidase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


[[1egu]], [[2brw]] – SpHU – ''Streptococcus pneumoniae'' <br />
*Hyaluronidase
[[1n7n]], [[1n7o]], [[1n7p]] – SpHU (mutant) <br />
[[1fcq]], [[1fcu]] – bHU – bee<br />
[[1f1s]] – SaHU – ''Streptococcus agalactiae'' <br />
[[2c3f]], [[2dp5]], [[2yw0]], [[2yx2]], [[2wb3]], [[2wh7]] - SpyHU – ''Streptococcus pyogenes''<br />
[[2cbi]], [[2w1q]], [[2w1s]] - CpHU – ''Clostridium perfringens''<br />
[[2jnk]] - CpHU residues 1498-1628]] - NMR<br />
[[2atm]] - HU – ''Vespula vulgaris''<br />
[[2pe4]] – HU-1 – human


===Hyaluronidase binary complex===
**[[1egu]], [[2brw]] – SpHU – ''Streptococcus pneumoniae'' <br />
**[[1n7n]], [[1n7o]], [[1n7p]] – SpHU (mutant) <br />
**[[1fcq]], [[1fcu]] – bHU – bee<br />
**[[1f1s]] – SaHU – ''Streptococcus agalactiae'' <br />
**[[2c3f]], [[2dp5]], [[2yw0]], [[2yx2]], [[2wb3]], [[2wh7]] - SpyHU – ''Streptococcus pyogenes''<br />
**[[2cbi]], [[2w1q]], [[2w1s]] - CpHU – ''Clostridium perfringens''<br />
**[[2jnk]] - CpHU residues 1498-1628]] - NMR<br />
**[[2atm]] - HU – ''Vespula vulgaris''<br />
**[[2pe4]] – HU-1 – human
 
*Hyaluronidase binary complex
 
**[[1c82]] – SpHU + HUA disaccharide <br />
**[[1f9g]] – SpHU + ascorbate <br />
**[[2brv]]– SpHU + malonate<br />
**[[1fcv]] - bHU + HUA<br />
**[[1i8q]] - SaHU + HUA disaccharide <br />
**[[1loh]], [[1lxk]] - SpHU + glucuronic acid<br />
**[[1n7q]], [[1n7r]] - SpHU (mutant) + glucuronic acid<br />
**[[1lxm]] - SaHU + glucuronic acid<br />
**[[1ojm]], [[1ojp]] - SpHU + condroitin disaccharide <br />
**[[1ojn]], [[1ojo]] - SpHU (mutant) + condroitin disaccharide <br />
**[[1w3y]] - SpHU + palmitoyl-vitamin C <br />
**[[2cbj]] - CpHU + PugNac<br />
**[[2j1a]] - CpHU + galactose<br />
**[[2j1e]] - CpHU + LacNac<br />
**[[2j7m]], [[2w1u]], [[2wdb]] - CpHU + carbohydrates<br />
**[[2j62]] - CpHU + GlcNac-statin<br />
**[[2brp]] – SpHU + inbhibitor<br />
**[[2j88]] - bHU + FAB<br />
**[[2yvv]] - SpyHU + lactose<br />
**[[3eka]] - SpyHU + ascorbate <br />
}}


[[1c82]] – SpHU + HUA disaccharide <br />
[[1f9g]] – SpHU + ascorbate <br />
[[2brv]]– SpHU + malonate<br />
[[1fcv]] - bHU + HUA<br />
[[1i8q]] - SaHU + HUA disaccharide <br />
[[1loh]], [[1lxk]] - SpHU + glucuronic acid<br />
[[1n7q]], [[1n7r]] - SpHU (mutant) + glucuronic acid<br />
[[1lxm]] - SaHU + glucuronic acid<br />
[[1ojm]], [[1ojp]] - SpHU + condroitin disaccharide <br />
[[1ojn]], [[1ojo]] - SpHU (mutant) + condroitin disaccharide <br />
[[1w3y]] - SpHU + palmitoyl-vitamin C <br />
[[2cbj]] - CpHU + PugNac<br />
[[2j1a]] - CpHU + galactose<br />
[[2j1e]] - CpHU + LacNac<br />
[[2j7m]], [[2w1u]], [[2wdb]] - CpHU + carbohydrates<br />
[[2j62]] - CpHU + GlcNac-statin<br />
[[2brp]] – SpHU + inbhibitor<br />
[[2j88]] - bHU + FAB<br />
[[2yvv]] - SpyHU + lactose<br />
[[3eka]] - SpyHU + ascorbate <br />
</StructureSection>
==Reference==
==Reference==
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17503783 17503783]
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17503783 17503783]

Revision as of 10:25, 27 November 2014

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3D structures of hyaluronidase

Updated on 27-November-2014

Reference

Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:17503783


Created with the participation of Osnat Herzberg, Eran Hodis, Joel L. Sussman, Jaime Prilusky.

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman