Obscurin

Obscurin (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see Group:MUZIC:Obscurin.

3D structures of obscurin

02-December-2014

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• Obscurin
  • 2e7b - hObs 6th Ig domain residues 8-97 – human - NMR
    
  • 2eny - hObs Ig domain residues 2735-2825 – NMR
    
  • 2edf - hObs 2nd Ig domain residues 2826-2915 – NMR
    
  • 2cr6 - hObs Ig domain residues 2998-3100 – NMR
    
  • 2yz8 - hObs 32nd Ig domain residues 3184-3273
    
  • 2edr - hObs Ig domain residues 3361-3449 – NMR
    
  • 2edt - hObs Ig domain residues 3449-3537 – NMR
    
  • 2edw - hObs I-set domain residues 3537-3630 – NMR
    
  • 2edh – hObs PDZ domain residues 3614-3713 – NMR
    
  • 2edq - hObs Ig domain residues 3713-3806 – NMR
    
  • 2edl - hObs Ig domain residues 3801-3897 – NMR
    
  • 1v1c - hObs SH3 domain residues 5601-5668 – NMR
    
• Obscurin-like protein 1
  • 2e6q - hObsL Ig domain residues 615-713 – NMR
    
  • 2e6p - hObsL Ig domain residues 714-804 – NMR
    
  • 3knb, 2wp3, 2wwm – hObs N terminal residues 1-105 + titin M10 domain
    
  • 2wwk – hObs N terminal residues 1-105 (mutant) + titin M10 domain
    

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Michal Harel, Alexander Berchansky