4r6u: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==IL-18 receptor complex==

== Structural highlights ==

<table><tr><td colspan='2'>[[4r6u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6U FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r6u RCSB], [http://www.ebi.ac.uk/pdbsum/4r6u PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Interleukin 18 (IL-18), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses. It signals through its ligand-binding primary receptor IL-18Ralpha and accessory receptor IL-18Rbeta. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Ralpha, which reveals the structural basis for their specific recognition. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand-receptor assembly and activation model for the IL-1 family.

~~The entry 4r6u is ON HOLD until Paper Publication~~

Structural basis for the specific recognition of IL-18 by its alpha receptor.,Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253<ref>PMID:25261253</ref>

~~Authors: Wei~~, H., Wang, X.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: IL-~~18 receptor complex~~

== References ==

__TOC__

</StructureSection>

[[Category: Wang, X.]]

[[Category: Wei, H.]]

[[Category: Beta-trefoil fold]]

[[Category: Ig-like fold]]

[[Category: Immune system]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==IL-18 receptor complex==
+<StructureSection load='4r6u' size='340' side='right' caption='[[4r6u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4r6u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6U FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r6u RCSB], [http://www.ebi.ac.uk/pdbsum/4r6u PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Interleukin 18 (IL-18), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses. It signals through its ligand-binding primary receptor IL-18Ralpha and accessory receptor IL-18Rbeta. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Ralpha, which reveals the structural basis for their specific recognition. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand-receptor assembly and activation model for the IL-1 family.
-The entry 4r6u is ON HOLD  until Paper Publication
+Structural basis for the specific recognition of IL-18 by its alpha receptor.,Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253<ref>PMID:25261253</ref>
-Authors: Wei, H., Wang, X.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: IL-18 receptor complex
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Wang, X.]]
+[[Category: Wei, H.]]
+[[Category: Beta-trefoil fold]]
+[[Category: Ig-like fold]]
+[[Category: Immune system]]