4ux6: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==

~~The entry~~ 4ux6 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance].

~~Authors~~: ~~Cheshire~~, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </td></tr>

~~Description~~: ~~The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Andrews, G.]]

[[Category: Beaton, H G.]]

[[Category: Birkinshaw, T.]]

[[Category: Boughton-Smith, N.]]

[[Category: Cheshire, D R.]]

[[Category: Connolly, S.]]

[[Category: Cook, T R.]]

[[Category: Cooper, A.]]

[[Category: Cooper, S L.]]

[[Category: Cox, D.]]

[[Category: Dixon, J.]]

[[Category: Gensmantel, N.]]

[[Category: Hamley, P J.]]

[[Category: Harrison, R.]]

[[Category: Hartopp, P.]]

[[Category: Kack, H.]]

[[Category: Luker, T.]]

[[Category: Mete, A.]]

[[Category: Millichip, I.]]

[[Category: Nicholls, D J.]]

[[Category: Pimm, A D.]]

[[Category: St-Gallay, S A.]]

[[Category: Wallace, A V.]]

[[Category: Drug design]]

[[Category: Oxidoreductase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==
+<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-The entry 4ux6 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
-Authors: Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-Description: The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Andrews, G.]]
+[[Category: Beaton, H G.]]
+[[Category: Birkinshaw, T.]]
+[[Category: Boughton-Smith, N.]]
+[[Category: Cheshire, D R.]]
+[[Category: Connolly, S.]]
+[[Category: Cook, T R.]]
+[[Category: Cooper, A.]]
+[[Category: Cooper, S L.]]
+[[Category: Cox, D.]]
+[[Category: Dixon, J.]]
+[[Category: Gensmantel, N.]]
+[[Category: Hamley, P J.]]
+[[Category: Harrison, R.]]
+[[Category: Hartopp, P.]]
+[[Category: Kack, H.]]
+[[Category: Luker, T.]]
+[[Category: Mete, A.]]
+[[Category: Millichip, I.]]
+[[Category: Nicholls, D J.]]
+[[Category: Pimm, A D.]]
+[[Category: St-Gallay, S A.]]
+[[Category: Wallace, A V.]]
+[[Category: Drug design]]
+[[Category: Oxidoreductase]]