4pl5: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pl5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4pl5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL5 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31L:3-METHOXY-5-METHYL-4-(MORPHOLIN-4-YL)BIPHENYL-4-OL'>31L</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31L:3-METHOXY-5-METHYL-4-(MORPHOLIN-4-YL)BIPHENYL-4-OL'>31L</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pl3|4pl3]], [[4pl4|4pl4]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pl3|4pl3]], [[4pl4|4pl4]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl5 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl5 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl5 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Al-awar, R | [[Category: Al-awar, R]] | ||
[[Category: Chiovitti, D | [[Category: Chiovitti, D]] | ||
[[Category: Duffy, N | [[Category: Duffy, N]] | ||
[[Category: Patterson, J B | [[Category: Patterson, J B]] | ||
[[Category: Sanches, M | [[Category: Sanches, M]] | ||
[[Category: Sicheri, F | [[Category: Sicheri, F]] | ||
[[Category: Talukdar, M | [[Category: Talukdar, M]] | ||
[[Category: Thevakumaran, N | [[Category: Thevakumaran, N]] | ||
[[Category: Endoribonuclease]] | [[Category: Endoribonuclease]] | ||
[[Category: Inhibitor complex]] | [[Category: Inhibitor complex]] | ||
[[Category: Schiff base]] | [[Category: Schiff base]] | ||
[[Category: Unfolded protein response]] | [[Category: Unfolded protein response]] | ||
