2mn3: Difference between revisions
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''' | ==Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)== | ||
<StructureSection load='2mn3' size='340' side='right' caption='[[2mn3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mn3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MN3 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b8w|1b8w]], [[1zue|1zue]], [[1bnb|1bnb]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mn3 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DEFBL_ORNAN DEFBL_ORNAN]] Has antimicrobial activity. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The three-dimensional structure of a chemically synthesized peptide that we have called 'intermediate' defensin-like peptide (Int-DLP), from the platypus genome, was determined by nuclear magnetic resonance (NMR) spectroscopy; and its antimicrobial activity was investigated. The overall structural fold of Int-DLP was similar to that of the DLPs and beta-defensins, however the presence of a third antiparallel beta-strand makes its structure more similar to the beta-defensins than the DLPs. Int-DLP displayed potent antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The four arginine residues at the N-terminus of Int-DLP did not affect the overall fold, but were important for its antimicrobial potency. | |||
Structure and antimicrobial activity of platypus 'intermediate' defensin-like peptide.,Torres AM, Bansal P, Koh JM, Pages G, Wu MJ, Kuchel PW FEBS Lett. 2014 May 2;588(9):1821-6. doi: 10.1016/j.febslet.2014.03.044. Epub, 2014 Mar 30. PMID:24694388<ref>PMID:24694388</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bansal, P S]] | |||
[[Category: Koh, J M.S]] | |||
[[Category: Kuchel, P W]] | |||
[[Category: Pages, G]] | |||
[[Category: Torres, A M]] | |||
[[Category: Wu, M J]] | |||
[[Category: Antimicrobial protein]] | |||
[[Category: Beta-defensin]] | |||
[[Category: Defensin-like peptide]] | |||
[[Category: Intermediate-dlp]] | |||
[[Category: Platypus defensin]] | |||
Revision as of 16:10, 19 January 2015
Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)
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