Proteinase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
* '''PRO A''' is a carboxylproteinase.<br /> | * '''PRO A''' is a carboxylproteinase.<br /> | ||
* '''PRO K''' is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO K is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO K is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin). | * '''PRO K''' is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO K is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO K is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin). | ||
</StructureSection> | |||
==3D structures of proteinase== | ==3D structures of proteinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*'''Proteinase A''' | |||
[[2sga]] – SgPRO – ''Streptomyces griseus''<br /> | **[[2sga]] – SgPRO – ''Streptomyces griseus''<br /> | ||
[[2jxr]], [[1fmu]], [[1fmx]] – yPRO - yeast<br /> | **[[2jxr]], [[1fmu]], [[1fmx]] – yPRO - yeast<br /> | ||
[[1sgc]] - SgPRO + chymostatin A<br /> | **[[1sgc]] - SgPRO + chymostatin A<br /> | ||
[[3sga]], [[4sga]], [[5sga]] - SgPRO + polypeptide inhibitor<br /> | **[[3sga]], [[4sga]], [[5sga]] - SgPRO + polypeptide inhibitor<br /> | ||
[[1dp5]], [[1dpj]], [[1g0v]] - yPRO + polypeptide inhibitor IA3<br /> | **[[1dp5]], [[1dpj]], [[1g0v]] - yPRO + polypeptide inhibitor IA3<br /> | ||
[[1fq5]] - yPRO + inhibitor | **[[1fq5]] - yPRO + inhibitor | ||
*'''Proteinase B''' | |||
[[3sgb]] – SgPRO + turkey ovomucoid inhibitor<br /> | **[[3sgb]] – SgPRO + turkey ovomucoid inhibitor<br /> | ||
[[1sgp]], [[1sgq]], [[1sgr]], [[1cso]], [[1ct0]], [[1ct2]], [[1ct4]], [[1ds2]], [[2sgp]], [[2nu3]], [[2nu4]] – SgPRO + turkey ovomucoid inhibitor (mutant)<br /> | **[[1sgp]], [[1sgq]], [[1sgr]], [[1cso]], [[1ct0]], [[1ct2]], [[1ct4]], [[1ds2]], [[2sgp]], [[2nu3]], [[2nu4]] – SgPRO + turkey ovomucoid inhibitor (mutant)<br /> | ||
[[4sgb]] - SgPRO + potato inhibitor | **[[4sgb]] - SgPRO + potato inhibitor | ||
*'''Proteinase K''' | |||
[[2prk]], [[1cnm]], [[1egq]], [[2id8]], [[2g4v]], [[2v8b]], [[3gt3]], [[3gt4]], [[3d9q]], [[3ddz]], [[3de0]] , [[3de1]], [[3de2]], [[3de3]], [[3de4]], [[3de5]], [[3de6]], [[3de7]], [[3dvq]], [[3dvr]], [[3dvs]], [[3dw1]], [[3dw3]], [[3dwe]], [[3i2y]], [[3i30]], [[3i37]], [[3i34]], [[3l1k]], [[3aj8]], [[3aj9]], [[3q40]], [[3q5g]], [[3qmp]], [[4b5l]], [[4fon]] – EaPRO + Ca – ''Engyodontium album'' <br /> | **[[2prk]], [[1cnm]], [[1egq]], [[2id8]], [[2g4v]], [[2v8b]], [[3gt3]], [[3gt4]], [[3d9q]], [[3ddz]], [[3de0]] , [[3de1]], [[3de2]], [[3de3]], [[3de4]], [[3de5]], [[3de6]], [[3de7]], [[3dvq]], [[3dvr]], [[3dvs]], [[3dw1]], [[3dw3]], [[3dwe]], [[3i2y]], [[3i30]], [[3i37]], [[3i34]], [[3l1k]], [[3aj8]], [[3aj9]], [[3q40]], [[3q5g]], [[3qmp]], [[4b5l]], [[4fon]] – EaPRO + Ca – ''Engyodontium album'' <br /> | ||
[[1ic6]] – EaPRO (mutant) + Ca <br /> | **[[1ic6]] – EaPRO (mutant) + Ca <br /> | ||
[[1ptk]], [[1ht3]] – EaPRO + Ca + Hg <br /> | **[[1ptk]], [[1ht3]] – EaPRO + Ca + Hg <br /> | ||
[[2pkc]] – EaPRO + Na <br /> | **[[2pkc]] – EaPRO + Na <br /> | ||
[[4dj5]] – EaPRO <br /> | **[[4dj5]] – EaPRO <br /> | ||
*Proteinase K complex with peptide | |||
[[3prk]], [[1p7v]], [[1p7w]] – EaPRO + Ca + peptide inhibitor <br /> | **[[3prk]], [[1p7v]], [[1p7w]] – EaPRO + Ca + peptide inhibitor <br /> | ||
[[1bjr]], [[2dqk]], [[2duj]] – EaPRO + Ca + lactoferrin peptide <br /> | **[[1bjr]], [[2dqk]], [[2duj]] – EaPRO + Ca + lactoferrin peptide <br /> | ||
[[2hd4]] – EaPRO + Ca + lactoferrin peptide inhibitor<br /> | **[[2hd4]] – EaPRO + Ca + lactoferrin peptide inhibitor<br /> | ||
[[2dp4]], [[3ptl]] – EaPRO + lactoferrin peptide <br /> | **[[2dp4]], [[3ptl]] – EaPRO + lactoferrin peptide <br /> | ||
[[1pek]], [[1pfg]] – EaPRO + peptide inhibitor <br /> | **[[1pek]], [[1pfg]] – EaPRO + peptide inhibitor <br /> | ||
[[1pj8]] – EaPRO + Hg + substrate analog peptide <br /> | **[[1pj8]] – EaPRO + Hg + substrate analog peptide <br /> | ||
[[2hpz]], [[2pq2]] – EaPRO + Ca + peptide <br /> | **[[2hpz]], [[2pq2]] – EaPRO + Ca + peptide <br /> | ||
[[3osz]] – EaPRO + Ca + antimicrobial peptide <br /> | **[[3osz]] – EaPRO + Ca + antimicrobial peptide <br /> | ||
[[2b6n]] – PRO + tripeptide - ''Serratia''<br /> | **[[2b6n]] – PRO + tripeptide - ''Serratia''<br /> | ||
*Proteinase K complex with small molecule | |||
[[2pwb]] – EaPRO + Ca + coumarin <br /> | **[[2pwb]] – EaPRO + Ca + coumarin <br /> | ||
[[2pyz]] – EaPRO + Ca + auramine <br /> | **[[2pyz]] – EaPRO + Ca + auramine <br /> | ||
[[2pwa]] – EaPRO + Ca + alanine boronic acid <br /> | **[[2pwa]] – EaPRO + Ca + alanine boronic acid <br /> | ||
[[1oyo]] – EaPRO + Ca + melanin monomer <br /> | **[[1oyo]] – EaPRO + Ca + melanin monomer <br /> | ||
[[3dyb]] – EaPRO + Ca + digalacturonic acid <br /> | **[[3dyb]] – EaPRO + Ca + digalacturonic acid <br /> | ||
*'''Proteinase 3C''' | |||
[[1qa7]] – PRO – Hepatitis virus<br /> | **[[1qa7]] – PRO – Hepatitis virus<br /> | ||
[[2vb0]] - PRO – Coxsakievirus | **[[2vb0]] - PRO – Coxsakievirus | ||
*'''H2-Proteinase''' | |||
[[1wni]] – PRO – ''Trimeresurus flavoviridis'' | **[[1wni]] – PRO – ''Trimeresurus flavoviridis'' | ||
*'''Aspartic Proteinase''' | |||
[[2asi]] – PRO – ''Rhizomucor miehei''<br /> | **[[2asi]] – PRO – ''Rhizomucor miehei''<br /> | ||
[[1zap]] – CaPRO – ''Candida albicans''<br /> | **[[1zap]] – CaPRO – ''Candida albicans''<br /> | ||
[[1izd]] - AoPRO – ''Aspergillus oryzae''<br /> | **[[1izd]] - AoPRO – ''Aspergillus oryzae''<br /> | ||
[[1eag]] – CaPRO + inhibitor <br /> | **[[1eag]] – CaPRO + inhibitor <br /> | ||
[[1fq4]] - yPRO + inhibitor<br /> | **[[1fq4]] - yPRO + inhibitor<br /> | ||
[[1j71]] - PRO + polypeptide inhibitor – ''Candida tropicalis''<br /> | **[[1j71]] - PRO + polypeptide inhibitor – ''Candida tropicalis''<br /> | ||
[[1ize]] - AoPRO + polypeptide-statin inhibitor<br /> | **[[1ize]] - AoPRO + polypeptide-statin inhibitor<br /> | ||
[[1wkr]] - PRO + polypeptide-statin inhibitor – ''Irpex lacteus'' | **[[1wkr]] - PRO + polypeptide-statin inhibitor – ''Irpex lacteus'' | ||
*'''Cysteine Proteinase''' | |||
[[2hrv]] – PRO 2A – human rhinovirus | **[[2hrv]] – PRO 2A – human rhinovirus | ||
*'''Serine Proteinase''' | |||
[[1s2n]], [[1sh7]] – PRO – ''Vibrio''<br /> | **[[1s2n]], [[1sh7]] – PRO – ''Vibrio''<br /> | ||
[[3s9a]], [[3s9b]] – RvPRO – Siamese Russell’s viper<br /> | **[[3s9a]], [[3s9b]] – RvPRO – Siamese Russell’s viper<br /> | ||
[[3s9c]], [[3sbk]] – RvPRO + human factor V polypeptide<br /> | **[[3s9c]], [[3sbk]] – RvPRO + human factor V polypeptide<br /> | ||
[[1ga1]], [[1ga4]], [[1ga6]], [[1nlu]] – PsPRO + iodotyrostatin fragment – ''Pseudomonas''<br /> | **[[1ga1]], [[1ga4]], [[1ga6]], [[1nlu]] – PsPRO + iodotyrostatin fragment – ''Pseudomonas''<br /> | ||
[[1kdv]], [[1kdy]], [[1kdz]], [[1ke1]], [[1ke2]] - PsPRO + polypeptide inhibitor | **[[1kdv]], [[1kdy]], [[1kdz]], [[1ke1]], [[1ke2]] - PsPRO + polypeptide inhibitor | ||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 11:27, 4 December 2014
| ||||||||||||
3D structures of proteinase
Updated on 04-December-2014
References
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, Michal Harel, Joel L. Sussman, Karsten Theis
