4v06: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain==

== Structural highlights ==

<table><tr><td colspan='2'>[[4v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V06 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V06 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v06 RCSB], [http://www.ebi.ac.uk/pdbsum/4v06 PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.

== Function ==

~~The entry 4v06 is ON HOLD~~

__TOC__

</StructureSection>

~~Authors~~: ~~Kopec~~, J., ~~Oberholzer~~, A.~~, Fitzpatrick~~, F., ~~Newman, J~~., ~~Tallant, C~~., Kiyani, W., ~~Shrestha, L~~., ~~Burgess-Brown, N~~., ~~von Delft, F~~., ~~Arrowsmith, C~~.~~, Edwards, A., Bountra~~, C., Yue, W.W.

[[Category: Tryptophan 5-monooxygenase]]

[[Category: Arrowsmith, C.]]

~~Description~~: ~~Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain~~

[[Category: Bountra, C.]]

[[Category: Burgess-Brown, N.]]

[[Category: Delft, F von.]]

[[Category: Edwards, A.]]

[[Category: Fitzpatrick, F.]]

[[Category: Kiyani, W.]]

[[Category: Kopec, J.]]

[[Category: Newman, J.]]

[[Category: Oberholzer, A.]]

[[Category: Shrestha, L.]]

[[Category: Tallant, C.]]

[[Category: Yue, W W.]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain==
+<StructureSection load='4v06' size='340' side='right' caption='[[4v06]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V06 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v06 RCSB], [http://www.ebi.ac.uk/pdbsum/4v06 PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
+== Function ==
-The entry 4v06 is ON HOLD
+__TOC__
+</StructureSection>
-Authors: Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
+[[Category: Tryptophan 5-monooxygenase]]
+[[Category: Arrowsmith, C.]]
-Description: Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
+[[Category: Bountra, C.]]
+[[Category: Burgess-Brown, N.]]
+[[Category: Delft, F von.]]
+[[Category: Edwards, A.]]
+[[Category: Fitzpatrick, F.]]
+[[Category: Kiyani, W.]]
+[[Category: Kopec, J.]]
+[[Category: Newman, J.]]
+[[Category: Oberholzer, A.]]
+[[Category: Shrestha, L.]]
+[[Category: Tallant, C.]]
+[[Category: Yue, W W.]]
+[[Category: Oxidoreductase]]