1esl: Difference between revisions
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|PDB= 1esl |SIZE=350|CAPTION= <scene name='initialview01'>1esl</scene>, resolution 2.0Å | |PDB= 1esl |SIZE=350|CAPTION= <scene name='initialview01'>1esl</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1esl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1esl OCA], [http://www.ebi.ac.uk/pdbsum/1esl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1esl RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation. | The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Crowther, R L.]] | [[Category: Crowther, R L.]] | ||
[[Category: Graves, B J.]] | [[Category: Graves, B J.]] | ||
[[Category: cell adhesion protein]] | [[Category: cell adhesion protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:47 2008'' | ||
