1l8b: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1l8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8B FirstGlance]. <br> | <table><tr><td colspan='2'>[[1l8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8B FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l8b RCSB], [http://www.ebi.ac.uk/pdbsum/1l8b PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l8b RCSB], [http://www.ebi.ac.uk/pdbsum/1l8b PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/IF4E_MOUSE IF4E_MOUSE]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:18805096</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Dadlez, M | [[Category: Dadlez, M]] | ||
[[Category: Darzynkiewicz, E | [[Category: Darzynkiewicz, E]] | ||
[[Category: Gingras, A C | [[Category: Gingras, A C]] | ||
[[Category: Jankowska-Anyszka, M | [[Category: Jankowska-Anyszka, M]] | ||
[[Category: Mak, P | [[Category: Mak, P]] | ||
[[Category: Marcotrigiano, J | [[Category: Marcotrigiano, J]] | ||
[[Category: Niedzwiecka, A | [[Category: Niedzwiecka, A]] | ||
[[Category: Sonenberg, N | [[Category: Sonenberg, N]] | ||
[[Category: Stepinski, J | [[Category: Stepinski, J]] | ||
[[Category: Wyslouch-Cieszynska, A | [[Category: Wyslouch-Cieszynska, A]] | ||
[[Category: 7-methylgpppg]] | [[Category: 7-methylgpppg]] | ||
[[Category: Cap]] | [[Category: Cap]] | ||
