1nde: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NDE FirstGlance]. <br> | <table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NDE FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [http://www.ebi.ac.uk/pdbsum/1nde PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [http://www.ebi.ac.uk/pdbsum/1nde PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Consler, T G | [[Category: Consler, T G]] | ||
[[Category: Go, N | [[Category: Go, N]] | ||
[[Category: Hale, R L | [[Category: Hale, R L]] | ||
[[Category: Henke, B R | [[Category: Henke, B R]] | ||
[[Category: Hohman, D R | [[Category: Hohman, D R]] | ||
[[Category: Jones, S A | [[Category: Jones, S A]] | ||
[[Category: Lambert, M H | [[Category: Lambert, M H]] | ||
[[Category: Lu, A T | [[Category: Lu, A T]] | ||
[[Category: Moore, J T | [[Category: Moore, J T]] | ||
[[Category: Moore, L B | [[Category: Moore, L B]] | ||
[[Category: Orband-Miller, L A | [[Category: Orband-Miller, L A]] | ||
[[Category: Robinett, R G | [[Category: Robinett, R G]] | ||
[[Category: Shearin, J | [[Category: Shearin, J]] | ||
[[Category: Spearing, P K | [[Category: Spearing, P K]] | ||
[[Category: Stewart, E L | [[Category: Stewart, E L]] | ||
[[Category: Turnbull, P S | [[Category: Turnbull, P S]] | ||
[[Category: Weaver, S L | [[Category: Weaver, S L]] | ||
[[Category: Williams, S P | [[Category: Williams, S P]] | ||
[[Category: Wisely, G B | [[Category: Wisely, G B]] | ||
[[Category: Er]] | [[Category: Er]] | ||
[[Category: Erb]] | [[Category: Erb]] | ||
