1fms: Difference between revisions
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|PDB= 1fms |SIZE=350|CAPTION= <scene name='initialview01'>1fms</scene>, resolution 1.9Å | |PDB= 1fms |SIZE=350|CAPTION= <scene name='initialview01'>1fms</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fms OCA], [http://www.ebi.ac.uk/pdbsum/1fms PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fms RCSB]</span> | |||
}} | }} | ||
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[[Category: Neidle, S.]] | [[Category: Neidle, S.]] | ||
[[Category: Simpson, I J.]] | [[Category: Simpson, I J.]] | ||
[[Category: dna-drug minor groove complex]] | [[Category: dna-drug minor groove complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:26:05 2008'' | ||
Revision as of 17:26, 30 March 2008
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| 1fms, resolution 1.9Å | |||||||||||||
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| Ligands: | D35, DA, DC, DG, DT, MG | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)
Overview
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
About this Structure
1FMS is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631
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