2h8p: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2h8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H8P FirstGlance]. <br> | <table><tr><td colspan='2'>[[2h8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H8P FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3H:(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL+NONANOATE'>B3H</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3H:(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL+NONANOATE'>B3H</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h8p RCSB], [http://www.ebi.ac.uk/pdbsum/2h8p PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h8p RCSB], [http://www.ebi.ac.uk/pdbsum/2h8p PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: MacKinnon, R | [[Category: MacKinnon, R]] | ||
[[Category: Muir, T W | [[Category: Muir, T W]] | ||
[[Category: Valiyaveetil, F I | [[Category: Valiyaveetil, F I]] | ||
[[Category: Channel]] | [[Category: Channel]] | ||
[[Category: Ester]] | [[Category: Ester]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Semi-synthetic]] | [[Category: Semi-synthetic]] | ||
