2f89: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2f89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F89 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2f89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F89 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f7m|2f7m]], [[2f8c|2f8c]], [[2f8z|2f8z]], [[2f92|2f92]], [[2f94|2f94]], [[2f9k|2f9k]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f7m|2f7m]], [[2f8c|2f8c]], [[2f8z|2f8z]], [[2f92|2f92]], [[2f94|2f94]], [[2f9k|2f9k]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f89 RCSB], [http://www.ebi.ac.uk/pdbsum/2f89 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f89 RCSB], [http://www.ebi.ac.uk/pdbsum/2f89 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bitsch, F | [[Category: Bitsch, F]] | ||
[[Category: Bourgier, E | [[Category: Bourgier, E]] | ||
[[Category: Geiser, M | [[Category: Geiser, M]] | ||
[[Category: Green, J R | [[Category: Green, J R]] | ||
[[Category: Hemmig, R | [[Category: Hemmig, R]] | ||
[[Category: Jahnke, W | [[Category: Jahnke, W]] | ||
[[Category: Kroemer, M | [[Category: Kroemer, M]] | ||
[[Category: Lehmann, S | [[Category: Lehmann, S]] | ||
[[Category: Ramage, P | [[Category: Ramage, P]] | ||
[[Category: Rieffel, S | [[Category: Rieffel, S]] | ||
[[Category: Rondeau, J M | [[Category: Rondeau, J M]] | ||
[[Category: Strauss, A | [[Category: Strauss, A]] | ||
[[Category: Bisphosphonate inhibitor]] | [[Category: Bisphosphonate inhibitor]] | ||
[[Category: Cholesterol biosynthesis]] | [[Category: Cholesterol biosynthesis]] | ||
