2dfk: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dfk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DFK FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dfk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DFK FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1foe|1foe]], [[1kz7|1kz7]], [[1kzg|1kzg]], [[1lb1|1lb1]], [[1ki1|1ki1]], [[1dbh|1dbh]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1foe|1foe]], [[1kz7|1kz7]], [[1kzg|1kzg]], [[1lb1|1lb1]], [[1ki1|1ki1]], [[1dbh|1dbh]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dfk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dfk RCSB], [http://www.ebi.ac.uk/pdbsum/2dfk PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dfk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dfk RCSB], [http://www.ebi.ac.uk/pdbsum/2dfk PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ARHG9_RAT ARHG9_RAT]] Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.<ref>PMID:10607391</ref> <ref>PMID:11727829</ref> <ref>PMID:15215304</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Connelly, J J | [[Category: Connelly, J J]] | ||
[[Category: Kim, E Y | [[Category: Kim, E Y]] | ||
[[Category: Kirsch, J | [[Category: Kirsch, J]] | ||
[[Category: Nassar, N | [[Category: Nassar, N]] | ||
[[Category: Schindelin, H | [[Category: Schindelin, H]] | ||
[[Category: Schwarz, G | [[Category: Schwarz, G]] | ||
[[Category: Winking, J | [[Category: Winking, J]] | ||
[[Category: Xiang, S | [[Category: Xiang, S]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Dh domain]] | [[Category: Dh domain]] | ||
[[Category: Ph domain]] | [[Category: Ph domain]] | ||
