2qq2: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2qq2]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QQ2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2qq2]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QQ2 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT7, BACH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT7, BACH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qq2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qq2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qq2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qq2 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/BACH_HUMAN BACH_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Palmitoyl-CoA hydrolase]] | [[Category: Palmitoyl-CoA hydrolase]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Berg, S van den | [[Category: Berg, S van den]] | ||
[[Category: Berglund, H | [[Category: Berglund, H]] | ||
[[Category: Busam, R | [[Category: Busam, R]] | ||
[[Category: Collins, R | [[Category: Collins, R]] | ||
[[Category: Dahlgren, L G | [[Category: Dahlgren, L G]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Flodin, S | [[Category: Flodin, S]] | ||
[[Category: Flores, A | [[Category: Flores, A]] | ||
[[Category: Graslund, S | [[Category: Graslund, S]] | ||
[[Category: Hallberg, B M | [[Category: Hallberg, B M]] | ||
[[Category: Hammarstrom, M | [[Category: Hammarstrom, M]] | ||
[[Category: Herman, M D | [[Category: Herman, M D]] | ||
[[Category: Holmberg-Schiavone, L | [[Category: Holmberg-Schiavone, L]] | ||
[[Category: Johansson, I | [[Category: Johansson, I]] | ||
[[Category: Kallas, A | [[Category: Kallas, A]] | ||
[[Category: Karlberg, T | [[Category: Karlberg, T]] | ||
[[Category: Kotenyova, T | [[Category: Kotenyova, T]] | ||
[[Category: Lehtio, L | [[Category: Lehtio, L]] | ||
[[Category: Moche, M | [[Category: Moche, M]] | ||
[[Category: Nordlund, P | [[Category: Nordlund, P]] | ||
[[Category: Nyman, T | [[Category: Nyman, T]] | ||
[[Category: Persson, C | [[Category: Persson, C]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Sagemark, J | [[Category: Sagemark, J]] | ||
[[Category: Stenmark, P | [[Category: Stenmark, P]] | ||
[[Category: Sundstrom, M | [[Category: Sundstrom, M]] | ||
[[Category: Thorsell, A G | [[Category: Thorsell, A G]] | ||
[[Category: Tresaugues, L | [[Category: Tresaugues, L]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Welin, M | [[Category: Welin, M]] | ||
[[Category: Acot7]] | [[Category: Acot7]] | ||
[[Category: C-terminal domain]] | [[Category: C-terminal domain]] | ||
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[[Category: Serine esterase]] | [[Category: Serine esterase]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Thioesterase]] | [[Category: Thioesterase]] | ||
Revision as of 17:23, 24 December 2014
Crystal structure of C-terminal domain of Human acyl-CoA thioesterase 7
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Palmitoyl-CoA hydrolase
- Arrowsmith, C H
- Berg, S van den
- Berglund, H
- Busam, R
- Collins, R
- Dahlgren, L G
- Edwards, A
- Flodin, S
- Flores, A
- Graslund, S
- Hallberg, B M
- Hammarstrom, M
- Herman, M D
- Holmberg-Schiavone, L
- Johansson, I
- Kallas, A
- Karlberg, T
- Kotenyova, T
- Lehtio, L
- Moche, M
- Nordlund, P
- Nyman, T
- Persson, C
- Structural genomic
- Sagemark, J
- Stenmark, P
- Sundstrom, M
- Thorsell, A G
- Tresaugues, L
- Weigelt, J
- Welin, M
- Acot7
- C-terminal domain
- Hydrolase
- Mitochondrion
- Serine esterase
- Sgc
- Thioesterase
